Talk:Developmental Signals - Sonic hedgehog: Difference between revisions
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==Some Recent Findings== | ==Some Recent Findings== | ||
===Ontogenetic expression of sonic hedgehog in the chicken subpallium=== | |||
Front Neuroanat. 2010 Jul 21;4. pii: 28. | |||
Bardet SM, Ferran JL, Sanchez-Arrones L, Puelles L. | |||
Unité de Génétique Moléculaire Animale-INRA UMR 1061, University of Limoges Limoges, France. | |||
Abstract | |||
Sonic hedgehog (SHH) is a secreted signaling factor that is implicated in the molecular patterning of the central nervous system (CNS), somites, and limbs in vertebrates. SHH has a crucial role in the generation of ventral cell types along the entire rostrocaudal axis of the neural tube. It is secreted early in development by the axial mesoderm (prechordal plate and notochord) and the overlying ventral neural tube. Recent studies clarified the impact of SHH signaling mechanisms on dorsoventral patterning of the spinal cord, but the corresponding phenomena in the rostral forebrain are slightly different and more complex. This notably involves separate Shh expression in the preoptic part of the forebrain alar plate, as well as in the hypothalamic floor and basal plates. The present work includes a detailed spatiotemporal description of the singular alar Shh expression pattern in the rostral preoptic forebrain of chick embryos, comparing it with FoxG1, Dlx5, Nkx2.1, and Nkx2.2 mRNA expression at diverse stages of development. As a result of this mapping, we report a subdivision of the preoptic region in dorsal and ventral zones; only the dorsal part shows Shh expression. The positive area impinges as well upon a median septocommissural preoptic domain. Our study strongly suggests tangential migration of Shh-positive cells from the preoptic region into other subpallial domains, particularly into the pallidal mantle and the intermediate septum. | |||
PMID: 20700498 | |||
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917215 | |||
===Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector=== | ===Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector=== | ||
Revision as of 15:20, 2 November 2010
Search All databases sonic hedgehog
Some Recent Findings
Ontogenetic expression of sonic hedgehog in the chicken subpallium
Front Neuroanat. 2010 Jul 21;4. pii: 28.
Bardet SM, Ferran JL, Sanchez-Arrones L, Puelles L.
Unité de Génétique Moléculaire Animale-INRA UMR 1061, University of Limoges Limoges, France. Abstract Sonic hedgehog (SHH) is a secreted signaling factor that is implicated in the molecular patterning of the central nervous system (CNS), somites, and limbs in vertebrates. SHH has a crucial role in the generation of ventral cell types along the entire rostrocaudal axis of the neural tube. It is secreted early in development by the axial mesoderm (prechordal plate and notochord) and the overlying ventral neural tube. Recent studies clarified the impact of SHH signaling mechanisms on dorsoventral patterning of the spinal cord, but the corresponding phenomena in the rostral forebrain are slightly different and more complex. This notably involves separate Shh expression in the preoptic part of the forebrain alar plate, as well as in the hypothalamic floor and basal plates. The present work includes a detailed spatiotemporal description of the singular alar Shh expression pattern in the rostral preoptic forebrain of chick embryos, comparing it with FoxG1, Dlx5, Nkx2.1, and Nkx2.2 mRNA expression at diverse stages of development. As a result of this mapping, we report a subdivision of the preoptic region in dorsal and ventral zones; only the dorsal part shows Shh expression. The positive area impinges as well upon a median septocommissural preoptic domain. Our study strongly suggests tangential migration of Shh-positive cells from the preoptic region into other subpallial domains, particularly into the pallidal mantle and the intermediate septum.
PMID: 20700498
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917215
Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector
http://www.pnas.org/content/107/30/13432.full http://www.ncbi.nlm.nih.gov/pubmed/20624968
- Dynamic Assignment and Maintenance of Positional Identity in the Ventral Neural Tube by the Morphogen Sonic Hedgehog http://www.ncbi.nlm.nih.gov/pubmed/20532235 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879390/
- All mammalian hedgehog proteins interact with CDO and BOC in a conserved manner. http://www.ncbi.nlm.nih.gov/pubmed/20519495
- Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway. http://www.ncbi.nlm.nih.gov/pubmed/19223390
- Dynamic interpretation of hedgehog signaling in the Drosophila wing disc. [1]
- Patched 1 is a crucial determinant of asymmetry and digit number in the vertebrate limb.[2]
- Uncoupling Sonic hedgehog control of pattern and expansion of the developing limb bud.[3] "One of the first changes we noted was that the dorsoventral polarity of the forebrain was disturbed, which manifested as a loss of Shh in the ventral telencephalon, a reduction in expression of the ventral markers Nkx2.1 and Dlx2, and a concomitant expansion of the dorsal marker Pax6. In addition to changes in the forebrain neuroectoderm, we observed altered gene expression patterns in the facial ectoderm. For example, Shh was not induced in the frontonasal ectoderm, and Ptc and Gli1 were reduced in both the ectoderm and adjacent mesenchyme."
- THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia.[4]
- Triphalangeal thumb-polysyndactyly syndrome and syndactyly type IV are caused by genomic duplications involving the long-range, limb-specific SHH enhancer.[5]
- Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning. [6]
A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube. [7]15741323
Some Recent Findings
- Patched 1 is a crucial determinant of asymmetry and digit number in the vertebrate limb. Butterfield NC, Metzis V, McGlinn E, Bruce SJ, Wainwright BJ, Wicking C. Development. 2009 Oct;136(20):3515-24. PMID: 19783740
- Sonic hedgehog-dependent synthesis of laminin alpha1 controls basement membrane assembly in the myotome. Anderson C, Thorsteinsdóttir S, Borycki AG. Development. 2009 Oct;136(20):3495-504. PMID: 19783738
- Molecular and tissue interactions governing induction of cranial ectodermal placodes. McCabe KL, Bronner-Fraser M. Dev Biol. 2009 Aug 15;332(2):189-95. Epub 2009 Jun 2. Review. PMID: 19500565
