Talk:Abnormal Development - Illegal Drugs: Difference between revisions
(Created page with ' ===Fetal effects of psychoactive drugs=== Clin Perinatol. 2009 Sep;36(3):595-619. Salisbury AL, Ponder KL, Padbury JF, Lester BM. Department of Pediatrics, Brown Center for th…') |
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===Fetal effects of psychoactive drugs=== | ===Fetal effects of psychoactive drugs=== | ||
Clin Perinatol. 2009 Sep;36(3):595-619. | Clin Perinatol. 2009 Sep;36(3):595-619. | ||
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PMID: 19732616 | PMID: 19732616 | ||
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2767264/?tool=pubmed | |||
Revision as of 07:12, 18 October 2010
Fetal effects of psychoactive drugs
Clin Perinatol. 2009 Sep;36(3):595-619.
Salisbury AL, Ponder KL, Padbury JF, Lester BM.
Department of Pediatrics, Brown Center for the Study of Children at Risk, Women and Infants Hospital of Rhode Island, 101 Dudley Street, Providence, RI 02905, USA. amy_salisbury@brown.edu Abstract Psychoactive drug use by pregnant women has the potential to effect fetal development; the effects are often thought to be drug-specific and gestational age dependent. This article describes the effects of three drugs with similar molecular targets that involve monoaminergic transmitter systems: cocaine, methamphetamine, and selective serotonin re-uptake inhibitors (SSRIs) used to treat maternal depression during pregnancy. We propose a possible common epigenetic mechanism for their potential effects on the developing child. We suggest that exposure to these substances acts as a stressor that affects fetal programming, disrupts fetal placental monoamine transporter expression and alters neuroendocrine and neurotransmitter system development. We also discuss neurobehavioral techniques that may be useful in the early detection of the effects of in utero drug exposure.
PMID: 19732616
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2767264/?tool=pubmed
