Talk:Abnormal Development - Bacterial Infection

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Trophoblast infection with Chlamydia pneumoniae and adverse pregnancy outcomes associated with placental dysfunction

Am J Obstet Gynecol. 2009 May;200(5):526.e1-7.

Gomez LM, Parry S.

Maternal and Child Research Program, Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA. Abstract OBJECTIVE: We sought to determine whether Chlamydia pneumoniae impairs invasive trophoblast function and is associated with preeclampsia.

STUDY DESIGN: We conducted cell viability and invasion assays using primary extravillous trophoblast cells isolated from first-trimester placentas. We performed a case-control study to identify C pneumoniae in trophoblast cells dissected by laser capture microscopy from placentas in women with severe preeclampsia and control subjects who delivered at term.

RESULTS: Trophoblast cell viability and invasion through extracellular matrices were decreased after infection with C pneumoniae (both P < .05). C pneumoniae DNA was detected in trophoblast cells in 15/48 cases but only 3/30 controls (odds ratio, 4.1; P = .02). Positive and negative controls yielded expected results.

CONCLUSION: C pneumoniae infection can reduce trophoblast invasion into the uterine wall and is associated with preeclampsia. Further investigation of the mechanisms by which C pneumoniae induces trophoblast dysfunction, and the identification of therapies to prevent adverse outcomes attributed to trophoblast dysfunction, are warranted.

PMID: 19375572 http://www.ncbi.nlm.nih.gov/pubmed/19375572

WWW Links

CDC (USA)

Public Health Training Network Epidemiology and Prevention of Vaccine-Preventable Diseases (viewable Webcasts requires Media Player) |

Advisory Committee on Immunization Practices (ACIP) Recommendations

Royal College of Obstetricians and Gynaecologists (UK)

Infection and Pregnancy - study group recommendations (Jun 2001)

References

Links: [#PubMedReviews Reviews] | [#PubMedArticles Articles] | [#OnlineTextbooks Online Textbooks] | [#SearchTextbooks Search Textbooks] | [#SearchPubMed Search PubMed] | [#Glossary Glossary]

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Search PubMed

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