Talk:2011 Group Project 11
--Mark Hill 07:35, 30 September 2011 (EST) Currently all students originally assigned to each group are listed as equal authors/contributors to their project. If you have not contributed the content you had originally agreed to, nor participated in the group work process, then you should contact the course coordinator immediately and either discuss your contribution or request removal from the group author list. Remember that all student online contributions are recorded by date, time and the actual contributed content. A similar email reminder will be sent to all current students.
Please note the Universities Policy regarding Plagiarism
In particular this example:
- "Claiming credit for a proportion of work contributed to a group assessment item that is greater than that actually contributed;"
Academic Misconduct carries penalties. If a student is found guilty of academic misconduct, the penalties include warnings, remedial educative action, being failed in an assignment or excluded from the University for two years.
2011 Projects: Turner Syndrome | DiGeorge Syndrome | Klinefelter's Syndrome | Huntington's Disease | Fragile X Syndrome | Tetralogy of Fallot | Angelman Syndrome | Friedreich's Ataxia | Williams-Beuren Syndrome | Duchenne Muscular Dystrolphy | Cleft Palate and Lip
uploaded another heading 'associated anomalies' --Tahmina Lata 10:58, 22 September 2011 (EST)
|Unilateral Cleft Lip||This type of cleft refers to cleft of the lip that have only occurred on one side of the lip.|
|Unilateral Cleft Palate||This type of cleft refers to a cleft of the soft palate that occurs on one side of the palate. The cleft starts medially and extends laterally.|
|Unilateral cleft lip with a cleft hard palate||This refers to a cleft that has extended through the lip and into the hard palate. This cleft is on only one side of the lip and palate.|
|Unilateral cleft lip with cleft hard and soft palate||This type of cleft refers to a cleft that extends through the lip, hard palate and into the soft palate. It also occurs on only one side.|
|Bilateral cleft palate||This refers to a cleft of the soft palate which occurs on both sides of the palate and appears as a opening medially.|
|Bilateral cleft lip||This refers to a cleft of the lip that has occurred on both sides of the lip. There are many variations of this.|
|Bilateral cleft lip with cleft hard palate||This refers to a cleft of the lip and hard palate that occurs on both sides.|
|Bilateral cleft lip with cleft hard and soft palate||This refers to a cleft that has occurred on both sides of the lip and extended into both the hard and soft palates resulting in an medial opening of the soft palate.|
hey guys heres the table so far. I'm having a bit of trouble uploading the photos and finding sources for the info in the middle but I'm working on it --Elizabeth Wren 10:36, 22 September 2011 (EST)
Hey guys, just letting you know whats on the page under aetiology and treatment has not been finalised. I will need to upload images and tables. --Fleur McGregor 09:55, 22 September 2011 (EST)
Team, Found some amazing radiology images but they are under copyright. Would like to brainstorm with you all to se how we can request access. http://radiology.rsna.org/content/217/1/236.long --Tahmina Lata 00:15, 22 September 2011 (EST)
Hey Rahul, I am still working on the resolution of the image, I am considering rediesigining the orginial design and increasing the font size. Will update on it soon. I also have uploaded another brief subsection 'Problems associated with Cleft Palate'-hope it is useful. --Tahmina Lata 23:56, 21 September 2011 (EST)
I have just uploaded the Draft section Genetic Configuration... It is under review since I'm doing this with Rahul. the final version will be integrated later on. --z3284061 21:37, 21 September 2011 (EST)
I think we should go with the Articles we have, because this is our project, yes we can have a look at the other textbooks. But in the end, remember, this is designed by us as a group! and the mdconsult website does not work! --z3284061 20:53, 21 September 2011 (EST)
Hey Meedo, pursuant to our conversation- here are the 2 links that seem to conflict.
and I've spotted an error in reference 40 and 41. The chapter referred to is chapter 9, not 10. The necessary changes have been made. Timeline should be up soon.
--Rahul Mohan 17:53, 21 September 2011 (EST)
Hey Rahul, I got that info from the text book but I'd probably go by what Dr Hill has. Beth --z3292953 12:20, 21 September 2011 (EST)
guys- i have a problem. in development so far- i'm trying to work on the time line for cleft lip/palate development. it so turns out that there's conflicting information everywhere. on one hand- we have (google turned this up for me) <http://embryology.med.unsw.edu.au/Notes/face2.htm> which is by Dr Hill- in which its stated that "Cleft lip and palate develop between the 4th and 8th week of gestation". On the other hand- we have what's already written up for the section under dev- which has it stated that cleft lip happens from/between carnegie stage 16 and 18- and cleft palate erin week 6 to 10 (which equates roughly to carnegie stage 15 onwards. if we follow what Dr HIll's said- that would amount to stages 10-around 21. so which do we follow?
--Rahul Mohan 23:45, 20 September 2011 (EST)
Hey Tahmina- the resolution could be slightly better. have you tried saving the document as a pdf file? with maximum resolution or something? I'm not entirely certain- but i'm fairly sure it can be done. mm. on another note, guys- here're a few resources that you could check out for your relevant sections if you haven't already:
http://www.organizedwisdom.com/Cleft_Palate (scroll down to the journals section) http://www.jci.org/articles/view/22154/version/1 (particularly helpful for genetic---Meedo) http://dev.biologists.org/content/103/Supplement/41.full.pdf (helpful for development- what i'm working on right now. the last bit on genes might be useful to meedo as well.)
--Rahul Mohan 23:00, 20 September 2011 (EST)
Guys I am parking this image here for the time being as the resolution has not come out that well and I would like some feedback from you to see if we should add this to the page.
--Tahmina Lata 20:33, 20 September 2011 (EST)
Ravichandra KS, Vijayaprasad KE, Vasa AA, Suzan S.
J Indian Soc Pedod Prev Dent. 2010 Oct-Dec;28(4):311-4.
PMID: 21273723 [PubMed - indexed for MEDLINE]
Permission to post figure: https://s100.copyright.com/CustomerAdmin/PLF.jsp?lID=2011090_1316046741757 picture: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086810/bin/nihms284150f2.jpg
I have also included a hand drawn hierarchical table as I could not format such table in wiki. hope it is not looking too poorly done. --Tahmina Lata 23:30, 14 September 2011 (EST)
I have tried to stretch as much as possible and uploaded my final versions of my headings. --Tahmina Lata 23:28, 14 September 2011 (EST)
I have uploaded my section which is just a DRAFT. References are not all completed, and my photos are to be uploaded soon with drawings. --Maqdad Al Saif 20:35, 14 September 2011 (EST)
As we have 5 people in our group we must have more content than other groups so I am adding a third heading 'Neuroembryology and functional anatomy of craniofacial cleft.' We really need to work hard on this as the page so far is not looking the best. I hope that someone will come up with an impressive table.
--Tahmina Lata 23:03, 8 September 2011 (EST)
I will be writing about 'Diagnosis of prenatal cleft lip and palate' for my second heading. --Tahmina Lata 22:44, 6 September 2011 (EST)
Here are some more useful links with photos in them.
--Tahmina Lata 22:46, 6 September 2011 (EST)
I have uploaded the timeline here and under the heading- 'History' I am just going to include some interesting historical facts but after researching the other heading- 'Developmental Process' it seems to coincide with developmental staging and so it might not be a good idea to have that as a broad heading. Please let me know if you have any ideas on another heading or I will come up with a different heading and research that. Let me know what you think--Tahmina Lata 22:55, 5 September 2011 EST)
Great Work finding the articles :) I noticed in the second article of Tahmina, you can use the pictures to make the content more interesting. The same goes for Fleur, the last 2 articles have great information and pictures.
let's try updating the page before the end of the weekend
Cheers Guys... --Maqdad Al Saif 16:57, 5 September 2011 (EST)
Here are the articles I am studying at this stage:
--Tahmina Lata 21:18, 4 September 2011 (EST)
I've found some pictures which we can either use in the gallery or on the front page.
about my work, it will be all updated during the break but I will share with you what I'm doing. Meedo
--z3284061 11:29, 1 September 2011 (EST)
I also found these useful
--Fleur McGregor 10:41, 1 September 2011 (EST)
Hey guys here some references I found that were kinda useful
Plast Reconstr Surg. 2011 Feb;127(2):812-21.The spectrum of median craniofacial dysplasia.Allam KA, Wan DC, Kawamoto HK, Bradley JP, Sedano HO, Saied S. PMID: 21285785
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Aug;112(2):249-57. Epub 2011 Jun 12.Comparison between multislice and cone-beam computerized tomography in the volumetric assessment of cleft palate.Albuquerque MA, Gaia BF, Cavalcanti MG. PMID: 21664153
Nat Rev Genet. 2011 Mar;12(3):167-78.Cleft lip and palate: understanding genetic and environmental influences.Dixon MJ, Marazita ML, Beaty TH, Murray JC. PMID:21331089
I also found the Larsons textbook had some stuff on cleft palate and lip.
Beth --z3292953 10:20, 1 September 2011 (EST)
Hey fellas, I reckon we could have inserted a brief discussion of the etymology of the word in the introduction. I don't reckon its big enough to warrant a heading of its own. Thus, I've gone ahead and taken the liberty to remove that heading from the page. Also included an "aetiology" section under development of disease- since its looking at causation of disease. Changed current research into Current and Future Research- to increase the scope of that heading.
--Rahul Mohan 12:48, 25 August 2011 (EST)
I am doing history and developmental process.
--Tahmina Lata 10:06, 25 August 2011 (EST)
There has been some changes in our page in terms of Subheading order.
Hey Rahul, I'd be happy to share the Genetic Configuration with you... and your comments have been taken into consideration.
--z3284061 11:43, 25 August 2011 (EST)
Thankyou z3284061 for the heads up on what to do.
I've put myself down as finding current research and associated figures. However- pertaining to the latter- this would involve finding figures and diagrams relevant to our research I suppose? I'm definitely not good at art- and as for the diagrams and pics- that would be dependent more on the content we come up with. Also, as a sub-section- isn't it weird to lump all animations and figures under one subsection- isolating it away from the rest of the topic? Thus being the case, I propose that we individually keep a look out for relevant animations under our own sub-heading and I would help out anyone doing a large topic. z3284061 has indicated that that genetic configuration is a large sub heading- so I'll be happy to help with that.
See you in a couple of hours, fellas.
--z3272325 04:18, 25 August 2011 (EST)
I think after we discussed last time, I'll be doing Pathophysiology and Genetic Configuration.Hmm, I just think it will be kinda big especially for Genetic Configuration :) if you guys find anything related to it, pleaase don't hesitate to post it in the discussion.
The only one who might not have been allocated to do something specific is z3272325- I think you are meant to do The Animations and figures + Current Associated research :)
Let's Start updating the page whenever we have information :)
Cheers --z3284061 23:11, 24 August 2011 (EST)
For the groupo project I will be researching Developmental Staging and Abnormaility Classification.
--z3292953 11:21, 24 August 2011 (EST)
I am researching the following sub headings: surgical timeline and etimiology. If you all post what you are researching we can forward any information we find regarding your sub heading. --Fleur McGregor 12:16, 23 August 2011 (EST)
Here's the image I've found. --Maqdad Al Saif 13:10, 18 August 2011 (EST)
completely forgot I was meant to add a picture here as well. My apologies. And the group discussion's picking up- shall be more productive henceforth. here's a pic for cleft palate.
Wow!! That is sad Meedo! I didnt know you were in hospital! Yes I think the condition is cleft lip and palate however I am working on the classifications of cleft lip as they can be disjoint at many different sites of the lip. --Tahmina Lata 10:11, 18 August 2011 (EST)
Fantasitc Work Tahmina!!!! I can See a flow coming up!!! and z3292953 - Great Photos!!!! Please save the references somewhere Safe :D
As for me, I haven't been able to attend classes since Thursday. I was at the hospital, extremely dysfunctional.
Anyways, I can say that we should finilize the topic to This one... I prefer not to change because it's week 5 now. It will be wise if we dig deeper in the topic and we shall get better information. I will start my search from tomorrow and sorry for the delay. I HAVE ONLY ONE QUESTION IS CLEFT PALATE and LIP KNOWN as the WHOLE condition??? --z3284061 23:46, 17 August 2011 (EST)
The earliest known history of cleft lip is based on a combination of religion, superstition, invention and charlatanism. While Greeks were indifferent of their existence, Spartans and Romans would kill the children with this condition as they were considered to harbour evil spirits.
Between (1295- 1351) the first to note the congenital origin of the cleft was made by Jean Yperman. He also classified the various forms of the condition and laid down the principles for their treatment.
Between (1537-1619) Fabricius ab Aquapendente first suggested the embryological basis of cleft lip.
This is how I started the history, please comment if you think anything needs changing. I will continue the list on and the references at the end.
--Tahmina Lata 20:00, 16 August 2011 (EST)
--z3292953 12:08, 16 August 2011 (EST)
Hi Guys, I have started working on pathophysiology & history and modified some of the headings to include ones that were more relevant for Cleft palate and Lip.
--Tahmina Lata 21:51, 15 August 2011 (EST)
Mice mutants exhibit cleft palate and umbilical hernia
--Tahmina Lata 19:16, 15 August 2011 (EST)
So after careful consideration we have come to realise that Cleft Palate/Lip will be a more relevant topic to create a page about. Some of you guys left last week when we registered this topic with Dr Hill. Please post here if you are still unsure of the topic. At this stage we are all reseraching different things on the topic so we can discuss about it this week.
--Tahmina Lata 16:44, 15 August 2011 (EST)
There appears to be no group discussion here on possible project topics?? --Mark Hill 23:55, 7 August 2011 (EST)
We have decided to research each subheading listed on the Group Project page and then share all the information found next week. We will then be able to determine a clearer structure to the page based on what literature is available.
--Tahmina Lata 12:34, 11 August 2011 (EST)
Review Article "Cystic fibrosis: pathogenesis and future treatment strategies"-This review summarizes our current understanding of the pathophysiology and treatment of cystic fibrosis lung disease
Research Article "Nasal endoscopic evaluation of children and adolescents with cystic fibrosis"-The questionnaire, clinical examination and especially nasal endoscopy performed as part of this research lead to a detailed assessment of the nasal characteristics of children and adolescents with cystic fibrosis. 
--Tahmina Lata 23:13, 10 August 2011 (EST)
I've modified the page with the required subheadings, we can change them later but it's important to get our heads around the foundations.
If have have anything to add, please do so. if you have any questions, post it here and we will try and help. --z3284061 22:52, 10 August 2011 (EST)
Novel concepts in evaluating antimicrobial therapy for bacterial lung infections in patients with cystic fibrosis.Rogers GB, Hoffman LR, Döring G. J Cyst Fibros.2011 Jul 18. [Epub ahead of print]
Vitamin D receptor agonists inhibit pro-inflammatory cytokine production from the respiratory epithelium in cystic fibrosis.McNally P, Coughlan C, Bergsson G, Doyle M, Taggart C, Adorini L, Uskokovic MR, El-Nazir B, Murphy P, Greally P, Greene CM, McElvaney NG.J Cyst Fibros. 2011 Jul 22.
--z3292953 15:59, 9 August 2011 (EST)
How are we going in the research process? Well, In case anyone wants to change the topic Tomorrow will be the last day we get to change! That’s if everyone agrees to do so.
For the time being, we are working on Cystic Fibrosis. I’ve found some interesting articles regarding the treatment. The first one is a research while the other 2 are both Reviews.
I’ve Moved the articles of z3292953 to the discussion Page :)
Looking forward to create a great wiki page. --z3284061 22:34, 10 August 2011 (EST)
1. Effect of VX-770 in Persons with Cystic Fibrosis and the G551D-CFTR Mutation
2. Recent advances in the treatment of Pseudomonas aeruginosa infections in cystic fibrosis
Chronic Pseudomonas aeruginosa lung infection in cystic fibrosis (CF) patients is caused by biofilm-growing mucoid strains. Biofilms can be prevented by early aggressive antibiotic prophylaxis or therapy, and they can be treated by chronic suppressive therapy. New results from one small trial suggest that addition of oral ciprofloxacin to inhaled tobramycin may reduce lung inflammation. Clinical trials with new formulations of old antibiotics for inhalation therapy (aztreonam lysine) against chronic P. aeruginosa infection improved patient-reported outcome, lung function, time to acute exacerbations and sputum density of P. aeruginosa. Other drugs such as quinolones are currently under investigation for inhalation therapy. A trial of the use of anti-Pseudomonas antibiotics for long-term prophylaxis showed no effect in patients who were not already infected. Use of azithromycin to treat CF patients without P. aeruginosa infection did not improve lung function. Here I review the recent advances in the treatment of P. aeruginosa lung infections with a focus on inhalation treatments targeted at prophylaxis and chronic suppressive therapy. 
3. Changes in strategies for optimal antibacterial therapy in cystic fibrosis.
Aggressive antibiotic therapy of bacterial airway infection is one of the main reasons for the dramatic increase in life expectancy over the last few decades. Staphylococcus aureus and Haemophilus influenzae are the predominant pathogens in younger patients, but the choice of antibiotic therapy against these pathogens remains highly controversial. There is general agreement that patients with pulmonary exacerbations should be treated and many cystic fibrosis (CF) centres will also try to eradicate bacteria in the absence of symptoms. Prophylactic antibiotic therapy, with anti-staphylococcal medications started at the time of diagnosis, is advocated by some groups but its positive effect remains unproven. In fact, recent studies have suggested that continuous prophylactic treatment with anti-staphylococcal antibiotics may increase the risk of early colonisation with Pseudomonas aeruginosa. P. aeruginosa is the main pathogen in older children with CF. While chronic airway infection with mucoid P. aeruginosa is considered irreversible, both the combination of oral ciprofloxacin with inhaled colistin and inhaled tobramycin alone has been used successfully in the early phase of colonisation. In patients chronically infected with P. aeruginosa, standard treatment of pulmonary exacerbations consists of intravenous combination therapy for 2-3 weeks. Controversy exists whether this treatment should be performed routinely every 3 months or only in the presence of a pulmonary exacerbation. Inhaled antibiotics such as tobramycin have been shown to improve lung function and reduce sputum density of P. aeruginosa, but both the optimal dose and the duration of therapy are unclear at the present time 
Review: Inhaled bronchodilators for cystic fibrosis. Halfhide C, Evans HJ, Couriel J. Cochrane Database of Systematic Reviews 2005, Issue 4. Art. No.: CD003428. DOI: 10.1002/14651858.CD003428.pub2 from http://www2.cochrane.org/reviews/en/ab003428.html
Research Article: Identification of airborne dissemination of epidemic multiresistant strains of Pseudomonas aeruginosa at a CF centre during a cross infection outbreak. Jones AM, Govan JR, Doherty CJ, Dodd ME. Isalska BJ, Stanbridge TN, Webb AK. Thorax 58(6), 525-527. from http://www.ncbi.nlm.nih.gov/pubmed/12775867 --Rahul Mohan 10:58, 11 August 2011 (EST)
- I would suggest expanding on the current and future research section, maybe add in links to current research institutes or research papers.
- Perhaps add an image in for problems associated with cleft palate, just to add some dynamics and colour to the page.
- Perhaps tabulate the treatment section just so that the information is clearer
- Placing words in bold, although it was just a little touch, helped to highlight the main points you were trying to get across which was good.
- Good incorporation of tables and different formatting styles
- Your introduction was clear, simple and straight to the point.
- You’re referencing needs to be tidied up; there are multiple entries from the same source that tends to clutter your reference section.
- Your timeline was extremely spaced out, I would suggest deleting the space between your dot points just so that it reads easier.
--z3332629 15:31, 22 September 2011 (EST)