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- 14:37, 5 August 2009 S8600021 talk contribs uploaded File:Trisomy 21 newborn.jpg (Trisomy 21 (Down Syndrome) Newborn Down syndrome or trisomy 21 is caused by nondisjunction of chromosome 21 in a parent who is chromosomally normal and is one of the most common chromosomal abnormalities in liveborn children. The frequency of trisom)