Quicktime Aschheim-Zondek Test 1928: Difference between revisions

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Revision as of 12:19, 15 November 2012

width=450px|height=625px|controller=true|autoplay=false</qt> This animation shows the basis of the historic 1928 Aschheim-Zondek Test for pregnancy.

The basis of the original historic Aschheim-Zondek[1] test developed in 1928 was to identify the changes in immature female mouse genital system by female human urine injected subcutaneously into these immature mice.

  • If the woman was pregnant - the presence of hormones (hCG) induced changes in the mouse genital tract physiologically similar to those produced by sex hormones.
    • follicle maturation, corpora heamorrhagicum and corpora lutea formation.
  • If the woman was not pregnant - there were no changes induced.

This early mouse test was later replaced with a similar, but simpler, urine test using the Xenopus frog.

Animation based upon original line drawings.[2]


Aschheim-Zondek Test 1928 Links: MP4 movie | Small Animation | Large Animation | Pregnancy Test | Menstrual Cycle | Human Chorionic Gonadotropin | Week 2 | Mouse Development | Frog Development | Movies

Reference

  1. Aschheim, S., and Zondek, B., Klin. Wschr., 7 8, 1401 (1928).
  2. <pubmed>20318243</pubmed>


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