Quicktime Aschheim-Zondek Test 1928: Difference between revisions

Revision as of 12:20, 15 November 2012

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This animation shows the basis of the historic 1928 Aschheim-Zondek Pregnancy Test.

The basis of the original historic Aschheim-Zondek^[1] test developed in 1928 was to identify the changes in immature female mouse genital system by female human urine injected subcutaneously into these immature mice.

If the woman was pregnant - the presence of hormones (hCG) induced changes in the mouse genital tract physiologically similar to those produced by sex hormones.
- follicle maturation, corpora heamorrhagicum and corpora lutea formation.
If the woman was not pregnant - there were no changes induced.

This early mouse test was later replaced with a similar, but simpler, urine test using the Xenopus frog.

Animation based upon original line drawings.^[2]

Reference

↑ Aschheim, S., and Zondek, B., Klin. Wschr., 7 8, 1401 (1928).
↑ <pubmed>20318243</pubmed>

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[1] Aschheim, S., and Zondek, B., Klin. Wschr., 7 8, 1401 (1928).

[2] <pubmed>20318243</pubmed>

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-| valign="top" |This animation shows the basis of the historic 1928 Aschheim-Zondek Test for pregnancy.
+| valign="top" |This animation shows the basis of the historic 1928 Aschheim-Zondek Pregnancy Test.
 The basis of the original historic Aschheim-Zondek<ref>Aschheim, S., and Zondek, B., Klin. Wschr., 7 8, 1401 (1928).</ref> test developed in 1928 was to identify the changes in immature female mouse genital system by female human urine injected subcutaneously into these immature mice.