Prostate Development

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Mouse

Androgenic regulation of ventral epithelial bud number and pattern in mouse urogenital sinus. Allgeier SH, Lin TM, Moore RW, Vezina CM, Abler LL, Peterson RE. Dev Dyn. 2010 Feb;239(2):373-85. PMID: 19941349

  • begins in fetal mice ductal progenitors (or buds) emerge from urogenital sinus epithelium
  • prostatic buds develop in response to androgens, which activate androgen receptors in UGS mesenchyme
  • two rows of 3-4 prostatic buds at birth
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