Human Spermatozoa Motility Movie: Difference between revisions

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<html5media height="520" width="512">File:Spermatozoa_motility_01.mp4</html5media>

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Human Spermatozoa Motility

This movie shows normal human spermatozoa motility and the response to the photo-release of progesterone.

Spermatozoa showing different types of responses to photorelease of progesterone, monitored at 30 frames/s. The flash for progesterone photorelease was at 5 s.

Both spermatozoa hyperactivation and the acrosome reaction are regulated by progesterone signalling, through activation of kinases present in the spermatozoa. These two processes appear to use different signalling pathways.

Links: MP4 version | spermatozoa | testis

Molecular

CatSper - cation channel of spermatozoa flagellum, calcium influx in response to progesterone through tyrosine phosphorylation mechanism. PMID 24813608
Slo3 - a potassium ion channel sets the membrane potential, in mouse allows potassium ions to leave spermatozoa and shifts the membrane voltage to more negative.
- Mouse Slo3 channel opened in response to a decrease in the concentration of protons within the sperm (increase in pH).
- Human Slo3 channel controlled by changes in the levels of calcium ions. PMID 24670955

Reference

Armon L & Eisenbach M. (2011). Behavioral mechanism during human sperm chemotaxis: involvement of hyperactivation. PLoS ONE , 6, e28359. PMID: 22163296 DOI.

Copyright

© 2011 Armon, Eisenbach. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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-:'''Links:''' [[Media:Spermatozoa_motility_01.mp4|MP4 version]] | [[Media:Spermatozoa_motility_01.mov|Quicktime version]] | [[Spermatozoa Development]] | [[Testis Development]]
+:'''Links:''' [[Media:Spermatozoa_motility_01.mp4|MP4 version]] | {{Spermatozoa}} | {{Testis}}
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 | [[File:Spermatozoa motility icon 01.jpg]]
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 ===Reference===
-<pubmed>22163296</pubmed>| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233563 PMC3233563] | [http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0028359 PLoS One.]
+{{#pmid:22163296}}
 ====Copyright====
 © 2011 Armon, Eisenbach. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.