Human Spermatozoa Motility Movie

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<html5media height="520" width="512">File:Spermatozoa_motility_01.mp4</html5media>

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Human Spermatozoa Motility

This movie shows normal human spermatozoa motility and the response to the photo-release of progesterone.

Spermatozoa showing different types of responses to photorelease of progesterone, monitored at 30 frames/s. The flash for progesterone photorelease was at 5 s.

Both spermatozoa hyperactivation and the acrosome reaction are regulated by progesterone signalling, through activation of kinases present in the spermatozoa. These two processes appear to use different signalling pathways.

Links: MP4 version | spermatozoa | testis
Spermatozoa motility icon 01.jpg Molecular
  • CatSper - cation channel of spermatozoa flagellum, calcium influx in response to progesterone through tyrosine phosphorylation mechanism. PMID 24813608
  • Slo3 - a potassium ion channel sets the membrane potential, in mouse allows potassium ions to leave spermatozoa and shifts the membrane voltage to more negative.
    • Mouse Slo3 channel opened in response to a decrease in the concentration of protons within the sperm (increase in pH).
    • Human Slo3 channel controlled by changes in the levels of calcium ions. PMID 24670955


Armon L & Eisenbach M. (2011). Behavioral mechanism during human sperm chemotaxis: involvement of hyperactivation. PLoS ONE , 6, e28359. PMID: 22163296 DOI.


© 2011 Armon, Eisenbach. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Cite this page: Hill, M.A. (2024, May 28) Embryology Human Spermatozoa Motility Movie. Retrieved from

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G