Human Spermatozoa Motility Movie

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Human Spermatozoa Motility

This movie shows normal human spermatozoa motility and the response to the photo-release of progesterone.

Spermatozoa showing different types of responses to photorelease of progesterone, monitored at 30 frames/s. The flash for progesterone photorelease was at 5 s.


Both spermatozoa hyperactivation and the acrosome reaction are regulated by progesterone signalling, through activation of kinases present in the spermatozoa. These two processes appear to use different signalling pathways.


Links: MP4 version | Quicktime version | Spermatozoa Development | Testis Development
Spermatozoa motility icon 01.jpg Molecular
  • CatSper - cation channel of spermatozoa flagellum, calcium influx in response to progesterone through tyrosine phosphorylation mechanism. PMID 24813608
  • Slo3 - a potassium ion channel sets the membrane potential, in mouse allows potassium ions to leave spermatozoa and shifts the membrane voltage to more negative.
    • Mouse Slo3 channel opened in response to a decrease in the concentration of protons within the sperm (increase in pH).
    • Human Slo3 channel controlled by changes in the levels of calcium ions. PMID 24670955

Reference

Leah Armon, Michael Eisenbach Behavioral mechanism during human sperm chemotaxis: involvement of hyperactivation. PLoS ONE: 2011, 6(12);e28359 PubMed 22163296

| PMC3233563 | PLoS One.


Copyright

© 2011 Armon, Eisenbach. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.