File:X inactivation Xist.jpg

From Embryology

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X inactivation Xist

The figure shows confocal images from a combined RNA-DNA FISH experiment for Xist in female mouse fibroblast cells (Female-biased expression of long non-coding RNAs in domains that escape X-inactivation in mouse.

"This study demonstrated that the amount of genes with sex-biased expression varies between individual brain regions in mouse. The sex-biased genes identified are localized on many chromosomes. At the same time, sexually dimorphic gene expression that is common to several parts of the brain is mostly restricted to the sex chromosomes. Moreover, the study uncovered multiple female-biased non-coding genes that are non-randomly co-localized on the X-chromosome with protein-coding genes that escape X-inactivation. This raises the possibility that expression of long non-coding RNAs may play a role in modulating gene expression in domains that escape X-inactivation in mouse."


Links: X Inactivation | Molecular Development | Female Development

Reference

Reinius B, Shi C, Hengshuo L, Sandhu KS, Radomska KJ, Rosen GD, Lu L, Kullander K, Williams RW & Jazin E. (2010). Female-biased expression of long non-coding RNAs in domains that escape X-inactivation in mouse. BMC Genomics , 11, 614. PMID: 21047393 DOI.

Copyright

Open access: Unrestricted use, distribution and reproduction in any medium is permitted, provided the original article is properly cited.

Original file name: Figure 5 (Labeling and size modified from original figure, contrast was adjusted to make the figure clear in thumbnail format)


Cite this page: Hill, M.A. (2024, June 21) Embryology X inactivation Xist.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:X_inactivation_Xist.jpg

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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current07:23, 22 November 2010Thumbnail for version as of 07:23, 22 November 20101,000 × 809 (104 KB)S8600021 (talk | contribs)==X inactivation Xist== The figure shows confocal images from a combined RNA-DNA FISH experiment for Xist in female mouse fibroblast cells (Female-biased expression of long non-coding RNAs in domains that escape X-inactivation in mouse. :" This study

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