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Varicocele induced cytoplasmic apoptosis

Energy dependent pathways in intact and varicocelized testes; Under normal conditions, glucose (GLU) is transferred the germinal cells via different GLU transporters, which supply enough energy for vital activities of cells such as germinal cell division. In contrast, lack of appropriate sources of energy forces the cells to switch energy sources from GLU to lipids. In order to use lipids the cells need adequate energy to synthesize essential enzymes such as lipase. In varicocele-induced animals synthesis of the lipase enzyme is down-regulated over time. Thus, the cells miss their ability to use the lipids as a secondary source of energy, which leads to remarkable reduction in cell division and continuation of vital functions. The induced impairments trigger cytoplasmic level apoptosis independent of the Fas pathway. [1]

Image Reference

Mazdak Razi, Hassan Malekinejad Varicocele-Induced Infertility in Animal Models. Int J Fertil Steril: 2013, 9(2);141-9

PMID 26246871

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  1. <pubmed> 26246871</pubmed>

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