File:Tooth molecular development.jpg

Stages of Molecular Tooth Development

Diagram showing stages of teeth development, a few genetic factors affecting phenotypes, and some signalling molecules and growth factors expressed in the epithelial and mesenchymal components of developing teeth.

While most teeth-related genes exhibit, in general, similar expression patterns in the developing teeth in both humans and mice, several genes, including MSX1, FGF8, PAX9, and SHOX2, show some slightly different expression profiles].

[Arrows = activation; (T) = inhibition at the indicated stages; italic fond = genes; regular, bold fond = growth factors.

"The ancestor of recent vertebrate teeth was a tooth-like structure on the outer body surface of jawless fishes. Over the course of 500,000,000 years of evolution, many of those structures migrated into the mouth cavity. In addition, the total number of teeth per dentition generally decreased and teeth morphological complexity increased. Teeth form mainly on the jaws within the mouth cavity through mutual, delicate interactions between dental epithelium and oral ectomesenchyme. These interactions involve spatially restricted expression of several, teeth-related genes and the secretion of various transcription and signaling factors."

Links: tooth

Reference

Koussoulakou DS, Margaritis LH & Koussoulakos SL. (2009). A curriculum vitae of teeth: evolution, generation, regeneration. Int. J. Biol. Sci. , 5, 226-43. PMID: 19266065

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Link: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2651620&rendertype=figure&id=F5 Original File Name: Ijbsv05p0226g05.jpg

Cite this page: Hill, M.A. (2024, April 27) Embryology Tooth molecular development.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Tooth_molecular_development.jpg

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G