File:Thymus Hassall's corpuscle.jpg
Thymus_Hassall's_corpuscle.jpg (800 × 451 pixels, file size: 84 KB, MIME type: image/jpeg)
Human Thymus Hassall's corpuscle
Human thymic stromal lymphopoietin (TSLP) activates thymic CD11c-positive dendritic cells.
a, TSLP immunostaining showing that Hassall's corpuscles in the thymic medulla express TSLP (red) (left panel). Double staining of TSLP and DC-LAMP showing an association between TSLP-positive Hassall's corpuscles (red) and DC-LAMP-positive activated dendritic cells (blue) (middle panel). Double staining of DC-LAMP and CD11c showing two dendritic cell populations: CD11c+DC-LAMP+ activated dendritic cells (dark brown) and CD11c+DC-LAMP- resting dendritic cells (blue) (right panel).
All scale bars, 50 µm.
b, c, Peripheral blood and thymic dendritic cells stimulated with TSLP or poly(I:C), or cultured in medium only. CD80, CD86 and HLA-DR expression as determined by flow cytometry (b). The numbers in the histograms indicate the mean fluorescence intensity. Production of TARC, MDC, IL-12p70 (the heterodimeric biologically active form of IL-12) and TNF-α by dendritic cells as determined by an enzyme-linked immunosorbent assay (c).
- Links: Hassall's corpuscles | thymus
Reference
Watanabe N, Wang YH, Lee HK, Ito T, Wang YH, Cao W & Liu YJ. (2005). Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus. Nature , 436, 1181-5. PMID: 16121185 DOI.
Copyright
Reprinted by permission from Macmillan Publishers Ltd: Nature (Hassall's corpuscles instruct dendritic cells to induce CD4 CD25 regulatory T cells in human thymus ), copyright (2005)
License Number: 2613520876942
Type Of Use: post on the internet
Original file name: Figure 1 Nature03886-f1.jpg
Cite this page: Hill, M.A. (2024, April 27) Embryology Thymus Hassall's corpuscle.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Thymus_Hassall%27s_corpuscle.jpg
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
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| current | 19:09, 21 February 2011 | | 800 × 451 (84 KB) | S8600021 (talk | contribs) | ==Human Thymus Hassall's corpuscle== Human TSLP activates thymic CD11c-positive dendritic cells. a, TSLP immunostaining showing that Hassall's corpuscles in the thymic medulla express TSLP (red) (left panel). Double staining of TSLP and DC-LAMP showing |
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