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Motor activities in spindle assembly

Microtubule (MT)-bound motors promote bipolar spindle formation, whereas chromosome-associated motors drive proper kinetochore orientation and chromosome movement to the equator.

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Motor-dependent mechanisms establish bipolarity as Eg5 (kinesin-5) motors slide antiparallel microtubules apart with their minus ends leading and their plus ends directed toward the spindle equator. Minus end–directed motors such as dynein move microtubules poleward with their minus ends leading, thereby incorporating K-fibers into the spindle and focusing spindle poles. Kinetochore-associated dynein transports chromosomes along astral microtubules toward the spindle poles from the periphery. Plus end–directed chromokinesins (kinesin-4 and -10) eject chromosome arms outward. CENP-E (kinesin-7) transports unattached kinetochores toward the equator along spindle microtubules. MTOC, microtubule organizing centre.


<pubmed>26668328</pubmed> Figure 3.

© 2015 Heald and Khodjakov.


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current16:04, 22 March 2016Thumbnail for version as of 16:04, 22 March 20161,200 × 978 (314 KB)Z8600021 (talk | contribs)===Reference=== <pubmed>26668328</pubmed> © 2015 Heald and Khodjakov. {{JCB}}

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