File:Spindle assembly motors 01.jpg: Difference between revisions

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Motor activities in spindle assembly

Microtubule (MT)-bound motors promote bipolar spindle formation, whereas chromosome-associated motors drive proper kinetochore orientation and chromosome movement to the equator.

Box 1	Box 2	Box 3	Box 4	Box 5
Motor-dependent mechanisms establish bipolarity as Eg5 (kinesin-5) motors slide antiparallel microtubules apart with their minus ends leading and their plus ends directed toward the spindle equator.	Minus end–directed motors such as dynein move microtubules poleward with their minus ends leading, thereby incorporating K-fibers into the spindle and focusing spindle poles.	Kinetochore-associated dynein transports chromosomes along astral microtubules toward the spindle poles from the periphery.	Plus end–directed chromokinesins (kinesin-4 and -10) eject chromosome arms outward.	CENP-E (kinesin-7) transports unattached kinetochores toward the equator along spindle microtubules. MTOC, microtubule organizing centre.

Reference

http://jcb.rupress.org/content/211/6/1103.full Figure 3.

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	Date/Time	Thumbnail	Dimensions	User	Comment
current	16:04, 22 March 2016		1,200 × 978 (314 KB)	Z8600021 (talk \| contribs)	===Reference=== <pubmed>26668328</pubmed> http://jcb.rupress.org/content/211/6/1103.full © 2015 Heald and Khodjakov. {{JCB}}

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Cell Division - Mitosis

@@ Line 8: / Line 8: @@
 ! Box 5
 |-
-| Box 1 Motor-dependent mechanisms establish bipolarity as Eg5 (kinesin-5) motors slide antiparallel microtubules apart with their minus ends leading and their plus ends directed toward the spindle equator.
+| Motor-dependent mechanisms establish bipolarity as Eg5 (kinesin-5) motors slide antiparallel microtubules apart with their minus ends leading and their plus ends directed toward the spindle equator.
-| Box 2 Minus end–directed motors such as dynein move microtubules poleward with their minus ends leading, thereby incorporating K-fibers into the spindle and focusing spindle poles.
+| Minus end–directed motors such as dynein move microtubules poleward with their minus ends leading, thereby incorporating K-fibers into the spindle and focusing spindle poles.
-| Box 3 Kinetochore-associated dynein transports chromosomes along astral microtubules toward the spindle poles from the periphery.
+| Kinetochore-associated dynein transports chromosomes along astral microtubules toward the spindle poles from the periphery.
-| Box 4 Plus end–directed chromokinesins (kinesin-4 and -10) eject chromosome arms outward.
+| Plus end–directed chromokinesins (kinesin-4 and -10) eject chromosome arms outward.
-| Box 5 CENP-E (kinesin-7) transports unattached kinetochores toward the equator along spindle microtubules. MTOC, microtubule organizing centre.
+| CENP-E (kinesin-7) transports unattached kinetochores toward the equator along spindle microtubules. MTOC, microtubule organizing centre.
 |}
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 [[Category:Mitosis]][[Category:Meiosis]][[Category:Cartoon]]
+[[Category:Cell Division]]