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Motor activities in spindle assembly

Microtubule (MT)-bound motors promote bipolar spindle formation, whereas chromosome-associated motors drive proper kinetochore orientation and chromosome movement to the equator.

Box 1: Motor-dependent mechanisms establish bipolarity as Eg5 (kinesin-5) motors slide antiparallel microtubules apart with their minus ends leading and their plus ends directed toward the spindle equator.

Box 2: Minus end–directed motors such as dynein move microtubules poleward with their minus ends leading, thereby incorporating K-fibers into the spindle and focusing spindle poles.

Box 3: Kinetochore-associated dynein transports chromosomes along astral microtubules toward the spindle poles from the periphery.

Box 4: Plus end–directed chromokinesins (kinesin-4 and -10) eject chromosome arms outward.

Box 5: CENP-E (kinesin-7) transports unattached kinetochores toward the equator along spindle microtubules. MTOC, microtubule organizing centre.

Reference

http://jcb.rupress.org/content/211/6/1103.full Figure 3.

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	Date/Time	Thumbnail	Dimensions	User	Comment
current	16:04, 22 March 2016		1,200 × 978 (314 KB)	Z8600021 (talk \| contribs)	===Reference=== <pubmed>26668328</pubmed> http://jcb.rupress.org/content/211/6/1103.full © 2015 Heald and Khodjakov. {{JCB}}

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Cell Division - Mitosis

@@ Line 1: / Line 1: @@
+==Motor activities in spindle assembly==
+Microtubule (MT)-bound motors promote bipolar spindle formation, whereas chromosome-associated motors drive proper kinetochore orientation and chromosome movement to the equator.
+{|
+| Box 1: Motor-dependent mechanisms establish bipolarity as Eg5 (kinesin-5) motors slide antiparallel microtubules apart with their minus ends leading and their plus ends directed toward the spindle equator.
+| Box 2: Minus end–directed motors such as dynein move microtubules poleward with their minus ends leading, thereby incorporating K-fibers into the spindle and focusing spindle poles.
+| Box 3: Kinetochore-associated dynein transports chromosomes along astral microtubules toward the spindle poles from the periphery.
+| Box 4: Plus end–directed chromokinesins (kinesin-4 and -10) eject chromosome arms outward.
+| Box 5: CENP-E (kinesin-7) transports unattached kinetochores toward the equator along spindle microtubules. MTOC, microtubule organizing centre.
+|}
 ===Reference===
@@ Line 4: / Line 13: @@
-http://jcb.rupress.org/content/211/6/1103.full
+http://jcb.rupress.org/content/211/6/1103.full Figure 3.
 © 2015 Heald and Khodjakov.