File:Sox transcription factors cartoon 01.jpg: Difference between revisions

Revision as of 18:38, 4 February 2015

Involvement of SOX proteins in various Developmental Pathways

Some of these signalling pathways have also been associated with tumorigenesis.

Reference

http://www.impactjournals.com/oncoscience/index.php?abs=46

Copyright

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

File history

Click on a date/time to view the file as it appeared at that time.

	Date/Time	Thumbnail	Dimensions	User	Comment
current	18:35, 4 February 2015		800 × 695 (81 KB)	Z8600021 (talk \| contribs)	==Involvement of SOX proteins in various developmental pathways== Some have also been associated with tumorigenesis. Oncoscience. 2014 Jun 2;1(5):326-35. eCollection 2014. SOX15 and other SOX family members are important mediators of tumorigenesis in...

You cannot overwrite this file.

File usage

The following page uses this file:

Developmental Signals - Sox

Metadata

This file contains additional information, probably added from the digital camera or scanner used to create or digitise it.

If the file has been modified from its original state, some details may not fully reflect the modified file.

Author	lpikor
Unique ID of original document	uuid:f22fbc5e-d69f-48b0-9acd-8e6a2155adea
Software used	Adobe Photoshop CS5.1 Windows
Short title	Slide 1
IIM version	2

@@ Line 1: / Line 1: @@
-==Involvement of SOX proteins in various developmental pathways==
+==Involvement of SOX proteins in various Developmental Pathways==
-Some have also been associated with tumorigenesis.
+Some of these signalling pathways have also been associated with tumorigenesis.
-Oncoscience. 2014 Jun 2;1(5):326-35. eCollection 2014.
-SOX15 and other SOX family members are important mediators of tumorigenesis in multiple cancer types.
+:'''Links:''' [[Developmental Signals - Sox]]
-Thu KL1, Becker-Santos DD1, Radulovich N1, Pikor LA1, Lam WL1, Tsao MS2.
-Author information
+===Reference===
-Abstract
+<pubmed>25594027</pubmed>
-SOX genes are transcription factors with important roles in embryonic development and carcinogenesis. The SOX family of 20 genes is responsible for regulating lineage and tissue specific gene expression patterns, controlling numerous developmental processes including cell differentiation, sex determination, and organogenesis. As is the case with many genes involved in regulating development, SOX genes are frequently deregulated in cancer. In this perspective we provide a brief overview of how SOX proteins can promote or suppress cancer growth. We also present a pan-cancer analysis of aberrant SOX gene expression and highlight potential molecular mechanisms responsible for their disruption in cancer. Our analyses indicate the prominence of SOX deregulation in different cancer types and reveal potential roles for SOX genes not previously described in cancer. Finally, we summarize our recent identification of SOX15 as a candidate tumor suppressor in pancreatic cancer and propose several research avenues to pursue to further delineate the emerging role of SOX15 in development and carcinogenesis.
-KEYWORDS:
-SOX; SOX15; cancer; development; oncogene; tumor suppressor
-PMID: 25594027 [PubMed] PMCID: PMC4278306
 http://www.impactjournals.com/oncoscience/index.php?abs=46
-http://www.impactjournals.com/oncoscience/files/papers/1/46/46.pdf
+====Copyright====
 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
+[[Category:Developmental Signal]] [[Category:Sox]] [[Category:Molecular]][[Category:Cartoon]]