File:SIRT1 cell distribution.jpg

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Spatial dynamics of SIRT1 and the subnuclear distribution of NADH species

Sirtuin 1 (SIRT1) is an NAD+-dependent deacetylase that functions as metabolic sensor of cellular energy and modulates biochemical pathways in the adaptation to changes in the environment.

NAD+ metabolism is compartmentalized

Schematic representation of the location of the different components of the NAD+ salvage pathway in different cellular compartments. The main metabolic pathways involved in the interconversion between the reduced and oxidized forms of NADH are indicated for each cellular compartment. NMNAT1–3, nicotinamide mononucleotide adenylyltransferase 1–3.

Reference

<pubmed>27791113</pubmed>


http://www.pnas.org/content/113/45/12715.long

text above modified from original paper.

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Cozzarelli NR, Fulton KR, Sullenberger DM. Liberalization of PNAS copyright policy: noncommercial use freely allowed. Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12399. PMID15314225 "Our guiding principle is that, while PNAS retains copyright, anyone can make noncommercial use of work in PNAS without asking our permission, provided that the original source is cited."

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Cite this page: Hill, M.A. (2024, June 24) Embryology SIRT1 cell distribution.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:SIRT1_cell_distribution.jpg

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