File:Rat blood–testis barrier 03.jpg

Rat Blood–Testis Barrier

A model depicting the migration of developing preleptotene spermatocytes across the blood–testis barrier (BTB}.

Migration during the seminiferous epithelial cycle of spermatogenesis utilizing the protein complexes of JAM/CTX and nectins at the Sertoli–germ cell interface.

(b) When germ cells move along Sertoli cells, the original JAM/CAR/nectin trans-homodimers between Sertoli cells are replaced by the Sertoli–germ cell junctions composed of CAR–CAR/CAR–JAM-C/nectin-2–nectin-3/necl-5(PVR)–necl-2/JAM-B–JAM-C complexes plausibly through competitive binding. It is noted that CAR–CAR adhesion has not been directly demonstrated for Sertoli cell–germ cell interaction, but remains an attractive possibility.

Links: Rat blood–testis barrier image | Movement of developing germ cells image | Rat blood–testis barrier junctions image |spermatozoa | sertoli cell | testis

Reference

Wang CQ & Cheng CY. (2007). A seamless trespass: germ cell migration across the seminiferous epithelium during spermatogenesis. J. Cell Biol. , 178, 549-56. PMID: 17698604 DOI.

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Figure 3.

Cite this page: Hill, M.A. (2024, April 27) Embryology Rat blood–testis barrier 03.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Rat_blood%E2%80%93testis_barrier_03.jpg

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