File:Rat blood–testis barrier 01.jpg
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Rat blood–testis barrier
A model depicting the migration of developing preleptotene spermatocytes across the blood–testis barrier (BTB}.
Migration during the seminiferous epithelial cycle of spermatogenesis utilizing the protein complexes of JAM/CTX and nectins at the Sertoli–germ cell interface.
(a) Movement of developing germ cells in the seminiferous epithelium of the adult testis. Germ cells first have to break through the tight junctions at the BTB with minimal disruptions. After the opening of the BTB, the progression of germ cells relies solely on series of transient adherens junctions at the Sertoli–germ cell interface. Assembly and disassembly of junctional complexes at the basal and apical ectoplasmic specialization occurs continuously.
(b) When germ cells move along Sertoli cells, the original JAM/CAR/nectin trans-homodimers between Sertoli cells are replaced by the Sertoli–germ cell junctions composed of CAR–CAR/CAR–JAM-C/nectin-2–nectin-3/necl-5(PVR)–necl-2/JAM-B–JAM-C complexes plausibly through competitive binding. It is noted that CAR–CAR adhesion has not been directly demonstrated for Sertoli cell–germ cell interaction, but remains an attractive possibility.
- Links: Rat blood–testis barrier image | Movement of developing germ cells image | Rat blood–testis barrier junctions image |spermatozoa | sertoli cell | testis
Reference
Wang CQ & Cheng CY. (2007). A seamless trespass: germ cell migration across the seminiferous epithelium during spermatogenesis. J. Cell Biol. , 178, 549-56. PMID: 17698604 DOI.
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Figure 3.
Cite this page: Hill, M.A. (2024, April 27) Embryology Rat blood–testis barrier 01.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Rat_blood%E2%80%93testis_barrier_01.jpg
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
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| current | 13:59, 1 May 2019 | | 1,002 × 1,599 (221 KB) | Z8600021 (talk | contribs) | |
| 13:59, 1 May 2019 |  | 1,100 × 2,255 (416 KB) | Z8600021 (talk | contribs) | A model depicting the migration of developing preleptotene spermatocytes across the blood–testis barrier (BTB} during the seminiferous epithelial cycle of spermatogenesis utilizing the protein complexes of JAM/CTX and nectins at the Sertoli–germ ce... |
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