File:Neural crest cell migration in erbb3b mutants.jpg

Fig. Neural crest cell migration is initially normal but later disrupted in erbb3b mutants

Description

Whole-mount labeling using crestin (A,B,E-H) or sox10 (C,D) riboprobes of wild-type embryos (A,C,E,G) and erbb3b mutants (B,D,F,H). At 24 hpf, both probes show that NC cell migration appears normal in erbb3b mutants (B,D) and in WT (A,C). At 27 (E,F) and 30 (G,H) hpf, NC cells form segmental streams ventral of the notochord in WT (E,G). In contrast, in erbb3b mutants (F,H) there are no streams at these stages, and NC cell migration is disrupted. Dotted lines represent dorsal aspect of the notochord. Lateral views, anterior to left. Scale bar 20 μm.

Reference

Honjo Y, Kniss J & Eisen JS. (2008). Neuregulin-mediated ErbB3 signaling is required for formation of zebrafish dorsal root ganglion neurons. Development , 135, 2615-25. PMID: 18599505 DOI.

Copyright

© 2008 Honjo et. al..This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Note - This image was originally uploaded as part of an undergraduate science student 2018 project and may contain inaccuracies in either description or acknowledgements. Students have been advised in writing concerning the reuse of content and may accidentally have misunderstood the original terms of use. If image reuse on this non-commercial educational site infringes your existing copyright, please contact the site editor for immediate removal.

Mark Hill (talk) 10:08, 18 October 2018 (AEDT) Description, reference, copyright and student template all correct. You could have provided additional descriptive information about the "erbb3b mutation", (Receptor tyrosine-protein kinase erbB-3) for example the linked information shown below.

• ZFIM - erb-b2 receptor tyrosine kinase 3b
• OMIM 190151 - TYROSINE KINASE-TYPE CELL SURFACE RECEPTOR HER3
• ERBB3 is a receptor for heregulin (NRG1; 142445) and is capable of mediating HGL-stimulated tyrosine phosphorylation of itself