File:Nephron EM02.jpg: Difference between revisions

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Glomerulus Podocyte EM

An ultrastructural overview of podocytes and the glomerular endothelium.

(A) Scanning electron micrograph of an exposed glomerulus. In this image, the Bowman’s capsule is broken, permitting a striking view of podocytes (Pod) completely wrapped around the glomerular capillaries.

(B) Higher magnification of a podocyte within the glomerulus revealing the interdigitated FPs.

(C) A resin cast of the glomerular capillary tuft with the cells corroded to reveal its highly convoluted shape. Image courtesy of F. Hossler (East Tennessee State University, Johnson City, TN).

(D) Scanning electron micrograph of an exposed glomerular capillary and its numerous perforations (fenestrae). (E) Simplified diagram of the GFB. The GEC and its fenestrae are lined by a filamentous glycocalyx enriched in negatively charged proteoglycans. The glycocalyx and adsorbed plasma components form the thicker ESL. The GBM is a stratified ECM in between podocytes and GECs. Podocytes form the final layer of the GFB. The interdigitating FPs of podocytes are linked by porous SDs where primary urinary filtrate passes through.

Bars: (A) 20 µm; (B and D) 1 µm; (C) 50 µm.

Links: colour image version | BW image version | renal histology

Reference

Scott RP & Quaggin SE. (2015). Review series: The cell biology of renal filtration. J. Cell Biol. , 209, 199-210. PMID: 25918223 DOI.

Copyright

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Figure 2. Relabelled. Text above modified from original figure legend.

Cite this page: Hill, M.A. (2024, May 8) Embryology Nephron EM02.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Nephron_EM02.jpg

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current	08:33, 18 May 2018		1,271 × 1,280 (210 KB)	Z8600021 (talk \| contribs)	Figure 2. An ultrastructural overview of podocytes and the glomerular endothelium. (A) Scanning electron micrograph of an exposed glomerulus. In this image, the Bowman’s capsule is broken, permitting a striking view of podocytes (Pod) completely wrap...

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@@ Line 1: / Line 1: @@
-Figure 2.
+==Glomerulus Podocyte EM==
-An ultrastructural overview of podocytes and the glomerular endothelium. (A) Scanning electron micrograph of an exposed glomerulus. In this image, the Bowman’s capsule is broken, permitting a striking view of podocytes (Pod) completely wrapped around the glomerular capillaries. (B) Higher magnification of a podocyte within the glomerulus revealing the interdigitated FPs. (C) A resin cast of the glomerular capillary tuft with the cells corroded to reveal its highly convoluted shape. Image courtesy of F. Hossler (East Tennessee State University, Johnson City, TN). (D) Scanning electron micrograph of an exposed glomerular capillary and its numerous perforations (fenestrae). (E) Simplified diagram of the GFB. The GEC and its fenestrae are lined by a filamentous glycocalyx enriched in negatively charged proteoglycans. The glycocalyx and adsorbed plasma components form the thicker ESL. The GBM is a stratified ECM in between podocytes and GECs. Podocytes form the final layer of the GFB. The interdigitating FPs of podocytes are linked by porous SDs where primary urinary filtrate passes through. Bars: (A) 20 µm; (B and D) 1 µm; (C) 50 µm.
+An ultrastructural overview of podocytes and the glomerular endothelium.
+(A) Scanning electron micrograph of an exposed glomerulus. In this image, the Bowman’s capsule is broken, permitting a striking view of podocytes (Pod) completely wrapped around the glomerular capillaries.
+(B) Higher magnification of a podocyte within the glomerulus revealing the interdigitated FPs.
+(C) A resin cast of the glomerular capillary tuft with the cells corroded to reveal its highly convoluted shape. Image courtesy of F. Hossler (East Tennessee State University, Johnson City, TN).
+(D) Scanning electron micrograph of an exposed glomerular capillary and its numerous perforations (fenestrae). (E) Simplified diagram of the GFB. The GEC and its fenestrae are lined by a filamentous glycocalyx enriched in negatively charged proteoglycans. The glycocalyx and adsorbed plasma components form the thicker ESL. The GBM is a stratified ECM in between podocytes and GECs. Podocytes form the final layer of the GFB. The interdigitating FPs of podocytes are linked by porous SDs where primary urinary filtrate passes through.
+Bars: (A) 20 µm; (B and D) 1 µm; (C) 50 µm.
+:'''Links:''' [[:File:Nephron EM02.jpg|colour image version]] | [[:File:Nephron EM01.jpg|BW image version]] | {{renal histology}}
-:'''Links:''' {{renal histology}}
 ===Reference===
@@ Line 9: / Line 24: @@
 {{JCB}}
-Figure 2. Panel B cropped resized, relabelled and converted to black and white image. Text above modified from figure legend.
+Figure 2. Relabelled. Text above modified from original figure legend.
 {{Footer}}
 [[Category:Renal]]
 [[Category:Electron Micrograph]]