File:Nephron EM02.jpg

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Glomerulus Podocyte EM

An ultrastructural overview of podocytes and the glomerular endothelium. SD - slit diaphragm

(A) Scanning electron micrograph of an exposed glomerulus. In this image, the Bowman’s capsule is broken, permitting a striking view of podocytes (Pod) completely wrapped around the glomerular capillaries.


(B) Higher magnification of a podocyte within the glomerulus revealing the interdigitated FPs.


(C) A resin cast of the glomerular capillary tuft with the cells corroded to reveal its highly convoluted shape. Image courtesy of F. Hossler (East Tennessee State University, Johnson City, TN).


(D) Scanning electron micrograph of an exposed glomerular capillary and its numerous perforations (fenestrae). (E) Simplified diagram of the GFB. The GEC and its fenestrae are lined by a filamentous glycocalyx enriched in negatively charged proteoglycans. The glycocalyx and adsorbed plasma components form the thicker ESL. The GBM is a stratified ECM in between podocytes and GECs. Podocytes form the final layer of the GFB. The interdigitating FPs of podocytes are linked by porous slit diaphragms (SDs) where primary urinary filtrate passes through.


Bars: (A) 20 µm; (B and D) 1 µm; (C) 50 µm.

Links: colour image version | BW image version | renal histology


Reference

Scott RP & Quaggin SE. (2015). Review series: The cell biology of renal filtration. J. Cell Biol. , 209, 199-210. PMID: 25918223 DOI.

Copyright

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Figure 2. Relabelled. Text above modified from original figure legend.


Cite this page: Hill, M.A. (2024, April 20) Embryology Nephron EM02.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Nephron_EM02.jpg

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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current08:33, 18 May 2018Thumbnail for version as of 08:33, 18 May 20181,271 × 1,280 (210 KB)Z8600021 (talk | contribs)Figure 2. An ultrastructural overview of podocytes and the glomerular endothelium. (A) Scanning electron micrograph of an exposed glomerulus. In this image, the Bowman’s capsule is broken, permitting a striking view of podocytes (Pod) completely wrap...

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