File:Mouse ruga pattern.jpg

From Embryology

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Mouse Palate Adult and E16

Palatal rugae are the transvere ridges forming on the secondary palate which are also sequentially added during development as the palate grows. Their number and arrangement on the hard palate of mammals is species specific. Along with the teeth and the tongue these ridges function in the process of mastication.

Figure shows the mouse ruga pattern in the adult and the fetus shown by in situ hybridization against Sonic hedgehog gene.

  • A - The roof of the oral cavity of an adult mouse showing the palatal ridges (rugae palatinae) on the hard palate.
  • B - Mouse rugae pattern with numbering used in this study. Note that ruga 7b was called 8b in other studies (Peterkova et al. 1987 PMID 3624420; Charles et al. 2007 PMID 18028050).
  • C - In ED16.0 fetus, Shh gene expression pattern (as seen by whole-mount in situ hybridization) prefigures the adult ruga pattern.
  • D - Sagittal section through the same embryo as in C, showing Shh expression in the epithelium at the tip of rugae (see magnification in the low left corner). The absence of Shh signal in the rugae 1–4 can be explained by its discontinuity in the anterior rugae at this stage (see C).

Links: Adult and E16 Palatal Rugae | E16 Palatal Rugae Mouse Development | Palate Development | Sonic hedgehog
From the paper - "We showed that palatal rugae are sequentially added to the growing palate, in an interposition process that appears to be dependent on activation-inhibition mechanisms and reveals a new developmental boundary in the growing palate. Further studies on rugae may help to shed light on both the development and evolution of structures arranged in regular patterns. Moreover, rugae will undoubtedly be powerful tools to further study the anteroposterior regionalization of the growing palate."


<pubmed>19087265</pubmed>| PMC2637861 | BMC Dev Biol.


© 2008 Pantalacci et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published online 2008 December 16. doi: 10.1186/1471-213X-8-116.

Original File Name: Figure 1. 1471-213X-8-116-1.jpg

Cite this page: Hill, M.A. (2024, June 12) Embryology Mouse ruga pattern.jpg. Retrieved from

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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current02:15, 29 March 2010Thumbnail for version as of 02:15, 29 March 2010600 × 1,059 (118 KB)S8600021 (talk | contribs)Mouse adult ruga pattern and its visualization in the fetus by in situ hybridization against Shh gene. (A) The roof of the oral cavity of an adult mouse showing the palatal ridges (rugae palatinae) on the hard palate. (B) Mouse rugae pattern with numb