File:Mouse-forelimb bud Fgf4-Hoxd13-Hoxa13.jpg: Difference between revisions

Latest revision as of 00:18, 2 September 2010

Mouse forelimb bud expression of Fgf4, Hoxd13, and Hoxa13

(A) Skeletal preparation (E14.5) wild-type forelimbs. Digit identities are indicated by numbers 1 (thumb, anterior) to 5 (little finger, posterior).

(B) Fgf4 expression in the AER of wild-type limb buds at E10.5 (36 somites). Arrowheads indicate the anterior and posterior margins of limb buds.

(C) Hoxd13 expression at E10.75 (40 somites). The late Hoxd13 expression domain in H2Δ/ΔcGli3Xt/Xt limb buds appears symmetrical in contrast to e.g. Gli3 deficient limb buds (expression borders are indicated by red lines). This is best seen by comparing apical views.

(D) Hoxa13 expression at E10.75 (41 somites). The Hoxa13 expression domain appears also symmetrical in H2Δ/ΔcGli3Xt/Xt limb buds, while some asymmetry is retained in Gli3 deficient limb buds

(red lines in dorsal views; best seen by comparing the apical views).

Original File name: Journal.pgen.1000901.g003.png Excerpt from Figure 7. showing only the normal limb gene expression.

Reference

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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	Date/Time	Thumbnail	Dimensions	User	Comment
current	02:45, 26 April 2010		881 × 237 (30 KB)	S8600021 (talk \| contribs)	Apolar expression of Fgf4, Hoxd13, and Hoxa13 in the autopod primordia of H2Δ/ΔcGli3Xt/Xt forelimb buds. Excerpt from Figure 7. showing only normal limb gene expression. (A) Skeletal preparation (E14.5) wild-type forelimbs. Digit identities are indica

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@@ Line 1: / Line 1: @@
-Mouse forelimb bud expression of Fgf4, Hoxd13, and Hoxa13.
+==Mouse forelimb bud expression of Fgf4, Hoxd13, and Hoxa13==
-Excerpt from Figure 7. showing only the normal limb gene expression.
 (A) Skeletal preparation (E14.5) wild-type forelimbs. Digit identities are indicated by numbers 1 (thumb, anterior) to 5 (little finger, posterior).
@@ Line 13: / Line 12: @@
 (red lines in dorsal views; best seen by comparing the apical views).
-Original File name: Journal.pgen.1000901.g003.png
+Original File name: Journal.pgen.1000901.g003.png Excerpt from Figure 7. showing only the normal limb gene expression.
-Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development. Galli A, Robay D, Osterwalder M, Bao X, Bénazet JD, Tariq M, Paro R, Mackem S, Zeller R. PLoS Genet. 2010 Apr 8;6(4):e1000901. [http://www.ncbi.nlm.nih.gov/pubmed/20386744 PMID: 20386744]
+==Reference==
-Citation: Galli A, Robay D, Osterwalder M, Bao X, Bénazet J-D, et al. (2010) Distinct Roles of Hand2 in Initiating Polarity and Posterior Shh Expression during the Onset of Mouse Limb Bud Development. PLoS Genet 6(4): e1000901. doi:10.1371/journal.pgen.1000901
+<pubmed>20386744</pubmed>
-Editor: Clifford J. Tabin, Harvard Medical School, United States of America
-Received: September 11, 2009; Accepted: March 9, 2010; Published: April 8, 2010
 This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
-[[Category:Limb]] [[Category:Mouse]]
+[[Category:Limb]] [[Category:Mouse]] [[Category:Mouse E10.5]] [[Category:Hox]]