File:Mouse-Sp2 mRNA expression.png

Sp2 mRNA expression in mouse embryos

Whole-mount in situ hybridization on embryos at the indicated developmental Theiler stages (E7.5-TS10, E7.75-TS11, E8.0-TS12 and E9.5-TS15) with the indicated probes (Sp2, Sp2 sense, Nkx-2.5 and GATA4).

The two embryos at E9.5 (TS15) represent two independent in situ hybridization experiments with embryos obtained from different litters.

Ac, amniotic cavity; Ba, first branchial arch; Hf, headfold; Fg, foregut; H, heart; Lb, limb bud; Nt, neuronal tissue; Op, optic pit; Ot, otic vesicle; S, somites; Tc, telencephalon.

The white arrowheads denote the boundary between embryonic and extraembryonic tissue.

Original File Name: Journal.pone.0009587.g001.png

http://www.plosone.org/article/info:doi%2F10.1371%2Fjournal.pone.0009587

Citation: Baur F, Nau K, Sadic D, Allweiss L, Elsässer H-P, et al. (2010) Specificity Protein 2 (Sp2) Is Essential for Mouse Development and Autonomous Proliferation of Mouse Embryonic Fibroblasts. PLoS ONE 5(3): e9587. doi:10.1371/journal.pone.0009587

Editor: Ferenc Mueller, University of Birmingham, United Kingdom

Received: December 23, 2009; Accepted: February 17, 2010; Published: March 8, 2010

Copyright: © 2010 Baur et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.