File:Molecular endocrine pancreas cells 01.jpg: Difference between revisions

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* '''Nkx2.2''' - NK2 Homeobox 2 [http://omim.org/entry/604612 OMIM 604612]
* '''Nkx2.2''' - NK2 Homeobox 2 [http://omim.org/entry/604612 OMIM 604612]
** homeobox (Hox) containing transcription factor contain a 60-amino acid evolutionarily conserved DNA-binding homeodomain.  
** homeobox (Hox) containing transcription factor contain a 60-amino acid evolutionarily conserved DNA-binding homeodomain.  
* '''Nkx6.1''' - NK2 Homeobox 6.1 [http://omim.org/entry/602563 OMIM 602563]
** homeobox (Hox) containing transcription factor contain a 60-amino acid evolutionarily conserved DNA-binding homeodomain.
** required for beta cells development and is completely conserved between rat, mouse, and human.
|}
|}


Revision as of 09:25, 31 August 2014

Molecular Development of Endocrine Pancreas Cells

Model placing gastrin cells in the transcriptional hierarchy of endocrine cells in the pancreas.

Four main endocrine adult cell types:
  1. alpha cells secreting glucagon
  2. beta cells secreting insulin
  3. delta cells secreting somatostatin
  4. PP cells secreting pancreatic polypeptide.
 Pancreatic G cells
  • similar to alpha cells in that it is dependent on Arx.
  • similar to epsilon cells in that both gastrin and ghrelin are frequently co-expressed with glucagon in the embryonic pancreas.
Links: Endocrine ancreas | Pax | Molecular Development
Factor Information
  • Pdx1 - Pancreas/Duodenum Homeobox Protein 1 OMIM 600733
    • transcription (transactivator) factor binds the TAAT element in the promoter region of target genes, mainly those involved in pancreas development.
  • Ngn3 - Neurogenin3 OMIM 604882
    • basic helix-loop-helix transcription factor involved in the determination of neural precursor cells in the neuroectoderm.
  • NeuroD1 - Neurogenic Differentiation 1 OMIM 601724
    • a basic helix-loop-helix (bHLH) protein that acts as a transcription factors involved in determining cell type during development.
  • Arx - Aristaless-Related Homeobox, X-Linked OMIM 300382
    • homeobox protein that belongs to the Aristaless-related subset of the paired (Prd) class of homeodomain proteins.
  • Pax4 - Paired Box Gene 4 OMIM 167413
    • transcription factor containing a paired box domain.
  • Pax6 Paired Box Gene 6 OMIM 607108
    • transcription factor containing a paired box domain.
  • Nkx2.2 - NK2 Homeobox 2 OMIM 604612
    • homeobox (Hox) containing transcription factor contain a 60-amino acid evolutionarily conserved DNA-binding homeodomain.
  • Nkx6.1 - NK2 Homeobox 6.1 OMIM 602563
    • homeobox (Hox) containing transcription factor contain a 60-amino acid evolutionarily conserved DNA-binding homeodomain.
    • required for beta cells development and is completely conserved between rat, mouse, and human.


References

<pubmed>23940571</pubmed>| PLoS One.

Copyright

© 2013 Suissa et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Journal.pone.0070397.g007.jpg

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