File:Model of Follicle Development.jpg

Model of Follicle Development

Model of a putative transcription network of gene, protein and hormonal stimulus of follicle development. The process starts with the formation of germ cells and continues with the development of oogonia and oocytes.

Several factors are involved in the PGC formation, oogonial (Oct-4), and oocyte development (Figα, Nobox, etc.).

Specific oocyte differentiation factors in preantral follicular stages are, YP30, ZP1-3 and those of cortical granulosa content: DF1,9 ovoperoxidase (Opo), proteoliasin (Pln), and rendivin (Rdv). PMFs: Primordial follicles, PF: primary follicle, SF: secondary follicle, IGF (family of the insulin-like growth factors).

(original figure legend, image based on data from Song and Wessel PMID 15733063)

Reference

<pubmed>22666170</pubmed>| ScientificWorldJournal

Copyright

© 2012 Gustavo Adolfo Palma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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