File:Model for multiple XIST RNA anchor points.jpg

Model for multiple XIST RNA anchor points impacting its localization to chromatin

(Interphase) In normal interphase cells, XIST RNA is tightly bound to the chromosome because of protein interactions at multiple anchor points. The loss of a single anchor point may not be sufficient to release XIST RNA from the chromosome.

(Mitosis) The normal loss of all anchor points at prophase in human cells releases XIST RNA from the chromosome. Inducing the retention of a single anchor point is sufficient to significantly retain XIST RNA on the chromosome. This study shows that at least one of the anchor points involved in human XIST RNA binding is regulated by Aurora B kinase (AURKB).

How XIST RNA strictly localizes across the inactive X chromosome is unknown; however, prophase release of human XIST RNA provides a clue.

References

Hall LL, Byron M, Pageau G & Lawrence JB. (2009). AURKB-mediated effects on chromatin regulate binding versus release of XIST RNA to the inactive chromosome. J. Cell Biol. , 186, 491-507. PMID: 19704020 DOI.

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Cite this page: Hill, M.A. (2024, April 28) Embryology Model for multiple XIST RNA anchor points.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Model_for_multiple_XIST_RNA_anchor_points.jpg

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G