File:Model BMP satellite cell differentiation.jpg

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Function of BMP signaling during satellite cell differentiation

Quiescent satellite cells (green) do not respond to BMP signals. Upon activation, satellite cells express MyoD and respond to BMP signals with phosphorylation of p-Smad (red) and reduced differentiation.

After satellite cell descendents are committed to differentiate (yellow) they express Myogenin and subsequently the BMP inhibitor Chordin.

Upon inhibition of BMP signaling, myoblasts exit the cell cycle, fuse into myotubes and undergo terminal differentiation (purple).

Postmitotic myonuclei (blue) irreversibly loose the competence to respond to BMP signals.

Figure 10

Reference

Friedrichs M, Wirsdöerfer F, Flohé SB, Schneider S, Wuelling M & Vortkamp A. (2011). BMP signaling balances proliferation and differentiation of muscle satellite cell descendants. BMC Cell Biol. , 12, 26. PMID: 21645366 DOI.

Copyright

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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Cite this page: Hill, M.A. (2024, June 24) Embryology Model BMP satellite cell differentiation.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Model_BMP_satellite_cell_differentiation.jpg

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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