File:Mesoderm development and Pax 01.jpg: Difference between revisions

Revision as of 10:25, 8 July 2014

Mesoderm Development and Pax

Pax gene hierarchies involved in the development of the progenitor populations of skeletal muscle, cartilage and tendon. Cells in the ventromedial part of the somite de-epithelialise and form the sclerotome (light green), in which Pax1 and Pax9 are expressed in a Shh-dependent manner.

As the dermomyotome elongates dorsomedially and ventrolaterally, PAX3 becomes restricted to the epaxial (red) and hypaxial (dark blue) lips, where a secondary generation of myocytes delaminate and migrate to form the epaxial (orange) and hypaxial (light blue) myotome. In the limb region, PAX3+ progenitors delaminate from the hypaxial dermamyotome (light blue) and migrate into the developing limbs to provide a pool of progenitors. In these cells, PAX3 regulates the hepatocyte growth factor receptor Met, which is necessary for hypaxial delamination and migration.

Pax7 is expressed principally within the central sheet of the dermomyotome (purple); when the final somite dissociates, Pax7+ progenitors delaminate into the developing myotome. These myotomal Pax3+ Pax7+ cells (pink) retain a progenitor state in order to become a resident population necessary for skeletal muscle growth as development proceeds.

The syndetome (dark green) originates from the dorsolateral edge of the sclerotome, as Pax1 and Pax9 are downregulated and scleraxis (Scx) upregulation leads to syndegenesis. Pax, paired homeobox; MYOD1, myogenic differentiation antigen 1; MYF5, myogenic factor 5; NKX, NK homeobox; SCX, scleraxis.

Reference

<pubmed>24496612</pubmed>| Development

Copyright

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Figure 4 http://dev.biologists.org/content/141/4/737/F4.expansion.html Original figure resized and relabelled. Text above modified from original figure legend.

File history

Click on a date/time to view the file as it appeared at that time.

	Date/Time	Thumbnail	Dimensions	User	Comment
current	10:22, 8 July 2014		1,211 × 1,000 (171 KB)	Z8600021 (talk \| contribs)	==Mesoderm Development and Pax== Pax gene hierarchies involved in the development of the progenitor populations of skeletal muscle, cartilage and tendon. Cells in the ventromedial part of the somite de-epithelialise and form the sclerotome (light gree...

You cannot overwrite this file.

File usage

The following 3 pages use this file:

Metadata

This file contains additional information, probably added from the digital camera or scanner used to create or digitise it.

If the file has been modified from its original state, some details may not fully reflect the modified file.

Software used	Adobe Photoshop CS6 Macintosh

@@ Line 1: / Line 1: @@
 ==Mesoderm Development and Pax==
-Pax gene hierarchies involved in the development of the progenitor populations of skeletal muscle, cartilage and tendon. Cells in the ventromedial part of the somite de-epithelialise and form the sclerotome (light green), in which Pax1 and Pax9 are expressed in a Shh-dependent manner. As the dermomyotome elongates dorsomedially and ventrolaterally, PAX3 becomes restricted to the epaxial (red) and hypaxial (dark blue) lips, where a secondary generation of myocytes delaminate and migrate to form the epaxial (orange) and hypaxial (light blue) myotome. In the limb region, PAX3+ progenitors delaminate from the hypaxial dermamyotome (light blue) and migrate into the developing limbs to provide a pool of progenitors. In these cells, PAX3 regulates the hepatocyte growth factor receptor Met, which is necessary for hypaxial delamination and migration. Pax7 is expressed principally within the central sheet of the dermomyotome (purple); when the final somite dissociates, Pax7+ progenitors delaminate into the developing myotome. These myotomal Pax3+ Pax7+ cells (pink) retain a progenitor state in order to become a resident population necessary for skeletal muscle growth as development proceeds. The syndetome (dark green) originates from the dorsolateral edge of the sclerotome, as Pax1 and Pax9 are downregulated and scleraxis (Scx) upregulation leads to syndegenesis. Pax, paired homeobox; MYOD1, myogenic differentiation antigen 1; MYF5, myogenic factor 5; NKX, NK homeobox; SCX, scleraxis.
+Pax gene hierarchies involved in the development of the progenitor populations of skeletal muscle, cartilage and tendon. Cells in the ventromedial part of the somite de-epithelialise and form the sclerotome (light green), in which Pax1 and Pax9 are expressed in a Shh-dependent manner.
+As the dermomyotome elongates dorsomedially and ventrolaterally, PAX3 becomes restricted to the epaxial (red) and hypaxial (dark blue) lips, where a secondary generation of myocytes delaminate and migrate to form the epaxial (orange) and hypaxial (light blue) myotome. In the limb region, PAX3+ progenitors delaminate from the hypaxial dermamyotome (light blue) and migrate into the developing limbs to provide a pool of progenitors. In these cells, PAX3 regulates the hepatocyte growth factor receptor Met, which is necessary for hypaxial delamination and migration.
-:'''Links:''' [[Developmental Signals - Pax]]
+Pax7 is expressed principally within the central sheet of the dermomyotome (purple); when the final somite dissociates, Pax7+ progenitors delaminate into the developing myotome. These myotomal Pax3+ Pax7+ cells (pink) retain a progenitor state in order to become a resident population necessary for skeletal muscle growth as development proceeds.
+The syndetome (dark green) originates from the dorsolateral edge of the sclerotome, as Pax1 and Pax9 are downregulated and scleraxis (Scx) upregulation leads to syndegenesis. Pax, paired homeobox; MYOD1, myogenic differentiation antigen 1; MYF5, myogenic factor 5; NKX, NK homeobox; SCX, scleraxis.
+{{Pax image links}}
 ===Reference===