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Subcortical structural changes along the menstrual cycle

Gray matter volumes extracted from the left and right hippocampus were significantly larger in the pre-ovulatory phase, when estradiol levels peak, compared to menses and luteal cycle phase. The effect was indeed driven by estradiol levels. Gray matter volumes extracted from the right basal ganglia were significantly larger in the luteal phase, when progesterone levels peak, compared to the pre-ovulatory phase. The effect was indeed driven by progesterone levels. (A) Hippocampal regions of interest, (B) Basal ganglia regions of interest, (C) Estradiol levels during the three cycle phases, (D) Progesterone levels during the three cycle phases, (E,F) Left and right hippocampal volumes during the three cycle phases, (G,H): left and right basal ganglia volumes during the three cycle phases. *p < 0.05, **p < 0.01, ***p < 0.001. Error bars represent standard errors.

Reference

Pletzer B, Harris T & Hidalgo-Lopez E. (2018). Subcortical structural changes along the menstrual cycle: beyond the hippocampus. Sci Rep , 8, 16042. PMID: 30375425 DOI.

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