File:Lymphatic vessel development.jpg

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Lymphatic Vessel Development

(a) In response to unknown factors, lymphatic differentiation is initiated by the polarized expression of Sox18 (yellow nuclei) in venous endothelium.

(b) Subsequently, Sox18 causes Prox1 expression (brown nuclei) leading to the exodus of lymphatic progenitors (yellow cells) from the cardinal veins and the formation of primary lymph sacs at distant sites.

(c) Sox18 expression subsides, but Prox1 expression is maintained in lymphatic endothelium, and lymphatics form by sprouting from the primitive lymph sacs.

(d) Genetic ablation of Prox1 from lymphatic endothelium results in dedifferentiation. Lymphatic-specific proteins are lost, whereas blood-vessel-specific proteins are re-expressed (magenta). Blood enters the lymphatics via aberrant connections, which could be caused by fusion of adjacent vessels (white arrow) or sprouting angiogenesis (grey arrow).

Links: Developmental Signals - Sox | OMIM - Sox18 | OMIM - Prox1
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1909 Lymph glands | 1912 Development of the Lymphatic System | 1918 Gray's Lymphatic Images | 1916 Pig Lymphatics | 1919 Chicken Lymphatic | 1921 Spleen | 1922 Pig Stomach Lymphatics | 1932 Cat Pharyngeal Tonsil | Historic Disclaimer

Reference

Kiefer F & Adams RH. (2008). Lymphatic endothelial differentiation: start out with Sox--carry on with Prox. Genome Biol. , 9, 243. PMID: 19138383 DOI.


Copyright

Authors of Research Articles, Methodologies and Software articles published in Genome Biology are the copyright holders of their articles and have granted to any third party, in advance and in perpetuity, the right to use, reproduce or disseminate the article, according to the BioMed Central copyright and license agreement.

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Cite this page: Hill, M.A. (2024, February 26) Embryology Lymphatic vessel development.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Lymphatic_vessel_development.jpg

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current08:58, 13 June 2012Thumbnail for version as of 08:58, 13 June 2012600 × 410 (92 KB)Z8600021 (talk | contribs)==Lymphatic Vessel Development== (a) In response to unknown factors, lymphatic differentiation is initiated by the polarized expression of Sox18 (yellow nuclei) in venous endothelium. (b) Subsequently, Sox18 causes Prox1 expression (brown nuclei) leadi