File:Lymph node structure 02.jpg: Difference between revisions

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Schematic representation of the organization of a lymph node.  
Schematic representation of the organization of a lymph node.  
* '''Afferent lymphatics''' enter lymph nodes and deliver lymph to the subcapsular sinus (SCS), which forms a channel around the periphery of the lymph node.  
* '''Afferent lymphatics''' enter lymph nodes and deliver lymph to the '''subcapsular sinus''' (SCS), which forms a channel around the periphery of the lymph node.  
* '''Lymphatic sinuses''' run from the SCS through the cortex to the medulla, and exit the lymph node via efferent lymphatic vessels on the opposite, hilar, side of the organ.
* '''Lymphatic sinuses''' run from the SCS through the cortex to the medulla
* B cell follicles containing follicular dendritic cell (FDC) networks are arranged in the lymph node cortex and are separated from the SCS by a layer of marginal reticular cells (MRC).
* '''Efferent lymphatics''' exit the lymph node via efferent lymphatic vessels on the opposite (hilar) side of the organ.
* The T cells zones in the paracortex, which contain many fibroblastic reticular cells (FRC), are separated by the cortical ridge, an area rich in T cells, dendritic cells (DCs), blood vessels, and FRC.  
* '''High endothelial venules''' (HEVs) - in the paracortex and cortical ridge, specialized  vessels allow entry of leukocytes from the blood.
* Blood vessels enter and exit the lymph node on the hilar side, and snake through the lymph node like the branches of a tree.  
* Blood vessels enter and exit the lymph node on the hilar side, and snake through the lymph node like the branches of a tree.  
* '''High endothelial venules''' (HEVs) - in the paracortex and cortical ridge, specialized  vessels allow entry of leukocytes from the blood.
 
* '''B cell follicles''' containing follicular dendritic cell (FDC) networks are arranged in the lymph node cortex and are separated from the SCS by a layer of marginal reticular cells (MRC).
* '''T cells zones''' in the paracortex, which contain many fibroblastic reticular cells (FRC), are separated by the cortical ridge, an area rich in T cells, dendritic cells (DCs), blood vessels, and FRC.  




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{{Lymph node cartoons}}
{{Lymph node cartoons}}


===Reference===
===Reference===
<pubmed>19644499</pubmed>| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785037 PMC2785037] | [http://www.nature.com/nri/journal/v9/n9/abs/nri2588.html Nat Rev Immunol.]
{{#pmid:19644499}}
 
[http://www.microbiol.unimelb.edu.au/research/immunology/s_mueller.html Mueller]
[http://www.microbiol.unimelb.edu.au/research/immunology/s_mueller.html Mueller]


====Copyright====
[[File_talk:Lymph_node_structure_02.jpg|Permissions]]
[[File_talk:Lymph_node_structure_02.jpg|Permissions]]


{{Footer}}
[[Category:Immune]]
[[Category:Immune]]

Latest revision as of 18:39, 30 April 2018

Lymph Node Structure

Schematic representation of the organization of a lymph node.

  • Afferent lymphatics enter lymph nodes and deliver lymph to the subcapsular sinus (SCS), which forms a channel around the periphery of the lymph node.
  • Lymphatic sinuses run from the SCS through the cortex to the medulla
  • Efferent lymphatics exit the lymph node via efferent lymphatic vessels on the opposite (hilar) side of the organ.
  • High endothelial venules (HEVs) - in the paracortex and cortical ridge, specialized vessels allow entry of leukocytes from the blood.
  • Blood vessels enter and exit the lymph node on the hilar side, and snake through the lymph node like the branches of a tree.
  • B cell follicles containing follicular dendritic cell (FDC) networks are arranged in the lymph node cortex and are separated from the SCS by a layer of marginal reticular cells (MRC).
  • T cells zones in the paracortex, which contain many fibroblastic reticular cells (FRC), are separated by the cortical ridge, an area rich in T cells, dendritic cells (DCs), blood vessels, and FRC.


Scale bars represent 200 μM.


Lymph Node Cartoons: Detailed structure | Cartoon with Histology | Lymphocyte traffic | Simple structure | Simple node anatomy | Wiki node image | Internal structure | Mesenteric lymph node | Histology | Gallery | Lymph Node Development


Reference

Mueller SN & Germain RN. (2009). Stromal cell contributions to the homeostasis and functionality of the immune system. Nat. Rev. Immunol. , 9, 618-29. PMID: 19644499 DOI. Mueller

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Cite this page: Hill, M.A. (2024, May 20) Embryology Lymph node structure 02.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Lymph_node_structure_02.jpg

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