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==Lymph node structure==
==Lymph Node Structure==


Schematic representation of the organization of a lymph node (left panel). Afferent lymphatics enter lymph nodes and deliver lymph to the subcapsular sinus (SCS), which forms a channel around the periphery of the lymph node. Lymphatic sinuses run from the SCS through the cortex to the medulla, and exit the lymph node via efferent lymphatic vessels on the opposite, hilar, side of the organ. B cell follicles containing follicular dendritic cell (FDC) networks are arranged in the lymph node cortex and are separated from the SCS by a layer of marginal reticular cells (MRC). The T cells zones in the paracortex, which contain many fibroblastic reticular cells (FRC), are separated by the cortical ridge, an area rich in T cells, dendritic cells (DCs), blood vessels, and FRC. Blood vessels enter and exit the lymph node on the hilar side, and snake through the lymph node like the branches of a tree. Specialized high endothelial venules (HEVs) in the paracortex and cortical ridge allow entry of leukocytes from the blood. An image of a mouse popliteal lymph node generated using multi-colour immunofluoresence microscopy illustrates the distribution of CD3+ T cells (white), B220+ B cells (blue), CD11c+ DCs (green), LYVE1+ (Lymphatic Vessel Endothelial Receptor 1) lymphatics (cyan), PNAd+ (peripheral node addressin) HEVs (yellow), and ER-TR7+ stromal cells (red) (centre panel). The organization of stromal cells in the lymph node is shown by single-colour immunofluoresence staining for ER-TR7 (right panel).  
Schematic representation of the organization of a lymph node.  
* '''Afferent lymphatics''' enter lymph nodes and deliver lymph to the '''subcapsular sinus''' (SCS), which forms a channel around the periphery of the lymph node.  
* '''Lymphatic sinuses''' run from the SCS through the cortex to the medulla
* '''Efferent lymphatics''' exit the lymph node via efferent lymphatic vessels on the opposite (hilar) side of the organ.
* '''High endothelial venules''' (HEVs) - in the paracortex and cortical ridge, specialized  vessels allow entry of leukocytes from the blood.
* Blood vessels enter and exit the lymph node on the hilar side, and snake through the lymph node like the branches of a tree.
 
* '''B cell follicles''' containing follicular dendritic cell (FDC) networks are arranged in the lymph node cortex and are separated from the SCS by a layer of marginal reticular cells (MRC).  
* '''T cells zones''' in the paracortex, which contain many fibroblastic reticular cells (FRC), are separated by the cortical ridge, an area rich in T cells, dendritic cells (DCs), blood vessels, and FRC.  




Scale bars represent 200 μM.
Scale bars represent 200 μM.
{{Lymph node cartoons}}


===Reference===
===Reference===
<pubmed>19644499</pubmed>| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785037 PMC2785037] | [http://www.nature.com/nri/journal/v9/n9/abs/nri2588.html Nat Rev Immunol.]
{{#pmid:19644499}}
 
[http://www.microbiol.unimelb.edu.au/research/immunology/s_mueller.html Mueller]
[http://www.microbiol.unimelb.edu.au/research/immunology/s_mueller.html Mueller]


====Copyright====
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[[Category:Immune]]

Latest revision as of 18:39, 30 April 2018

Lymph Node Structure

Schematic representation of the organization of a lymph node.

  • Afferent lymphatics enter lymph nodes and deliver lymph to the subcapsular sinus (SCS), which forms a channel around the periphery of the lymph node.
  • Lymphatic sinuses run from the SCS through the cortex to the medulla
  • Efferent lymphatics exit the lymph node via efferent lymphatic vessels on the opposite (hilar) side of the organ.
  • High endothelial venules (HEVs) - in the paracortex and cortical ridge, specialized vessels allow entry of leukocytes from the blood.
  • Blood vessels enter and exit the lymph node on the hilar side, and snake through the lymph node like the branches of a tree.
  • B cell follicles containing follicular dendritic cell (FDC) networks are arranged in the lymph node cortex and are separated from the SCS by a layer of marginal reticular cells (MRC).
  • T cells zones in the paracortex, which contain many fibroblastic reticular cells (FRC), are separated by the cortical ridge, an area rich in T cells, dendritic cells (DCs), blood vessels, and FRC.


Scale bars represent 200 μM.


Lymph Node Cartoons: Detailed structure | Cartoon with Histology | Lymphocyte traffic | Simple structure | Simple node anatomy | Wiki node image | Internal structure | Mesenteric lymph node | Histology | Gallery | Lymph Node Development


Reference

Mueller SN & Germain RN. (2009). Stromal cell contributions to the homeostasis and functionality of the immune system. Nat. Rev. Immunol. , 9, 618-29. PMID: 19644499 DOI. Mueller

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Cite this page: Hill, M.A. (2024, May 20) Embryology Lymph node structure 02.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Lymph_node_structure_02.jpg

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