File:Lymph node cartoon 02.jpg: Difference between revisions
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* (FRCs) form channels (FRC conduits) that project from the subcapsular sinus into the T-cell zone. | * (FRCs) form channels (FRC conduits) that project from the subcapsular sinus into the T-cell zone. | ||
* Some chemokines produced extranodally might reach HEVs through the FRC conduit. | * Some chemokines produced extranodally might reach HEVs through the FRC conduit. | ||
===Legend=== | |||
* B - B-cell zones | |||
* DC - dendritic cells | |||
* FRC - fibroblastic reticular cells | |||
* HEV - high endothelial venules | |||
Revision as of 09:50, 28 February 2012
Cell Trafficking into and out of Lymph Nodes
Lymphocytes and dendritic cells (DCs) enter lymph nodes by different routes.
Lymphocytes
- Most lymphocytes migrating to lymph nodes enter from the peripheral blood.
- Although various types of leukocyte are found in the arteries of lymph nodes, only lymphocytes can interact with and extravasate through high endothelial venules (HEVs) to migrate into the lymph-node parenchyma.
- T and B cells (lymphocytes) subsequently segregate into the T-cell zones and B-cell zones.
Dendritic cells
- DCs, together with small numbers of lymphocytes, enter lymph nodes through the afferent lymphatics.
- then accumulate in the vicinity of high endothelial venules.
- high endothelial venules are surrounded by fibroblastic reticular cells (FRCs)
Fibroblastic reticular cells
- (FRCs) form channels (FRC conduits) that project from the subcapsular sinus into the T-cell zone.
- Some chemokines produced extranodally might reach HEVs through the FRC conduit.
Legend
- B - B-cell zones
- DC - dendritic cells
- FRC - fibroblastic reticular cells
- HEV - high endothelial venules
- Lymph Node Cartoons: Detailed structure | Cartoon with Histology | Lymphocyte traffic | Simple structure | Simple node anatomy | Wiki node image | Internal structure | Mesenteric lymph node | Histology | Gallery | Lymph Node Development
Reference
<pubmed>15122201</pubmed>| Nat Rev Immunol.
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