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Cell Trafficking into and out of Lymph Nodes

Lymphocytes and dendritic cells (DCs) enter lymph nodes by different routes.


  • Most lymphocytes migrating to lymph nodes enter from the peripheral blood.
  • All leukocyte types are found in the arteries of lymph nodes.
  • Only lymphocytes can interact with and extravasate through high endothelial venules (HEVs) to migrate into the lymph node parenchyma.
  • T and B cells (lymphocytes) subsequently segregate into the T-cell zones and B-cell zones.


  • B - B-cell zones
  • DC - dendritic cells
  • FRC - fibroblastic reticular cells
  • HEV - high endothelial venues

Dendritic cells

  • Dendritic cells (DCs) with small numbers of lymphocytes enter lymph nodes through the afferent lymphatics.
  • then accumulate in the vicinity of high endothelial venules.
  • high endothelial venules are surrounded by fibroblastic reticular cells (FRCs)

Fibroblastic reticular cells

  • (FRCs) form channels (FRC conduits) that project from the subcapsular sinus into the T-cell zone.
  • Some chemokines produced extranodally might reach HEVs through the FRC conduit.

See also Lymph node - high endothelial venule cartoon.

Lymph Node Cartoons: Detailed structure | Cartoon with Histology | Lymphocyte traffic | Simple structure | Simple node anatomy | Wiki node image | Internal structure | Mesenteric lymph node | Histology | Gallery | Lymph Node Development


Miyasaka M & Tanaka T. (2004). Lymphocyte trafficking across high endothelial venules: dogmas and enigmas. Nat. Rev. Immunol. , 4, 360-70. PMID: 15122201 DOI.


Adapted by permission from Macmillan Publishers Ltd: Nat. Rev. Immunol.: 2004, 4(5);360-70, copyright (2004)

Licensee: Mark A Hill License Number: 2857291045727 Publication: Nature Reviews Immunology

Title: Lymphocyte trafficking across high endothelial venules: dogmas and enigmas Type Of Use: post on the internet

Cite this page: Hill, M.A. (2024, February 21) Embryology Lymph node cartoon 02.jpg. Retrieved from

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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