File:Lung human and mouse Sox expression.jpg

From Embryology

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Respiratory Development Human and Mouse Sox Expression

The lung originates from a region of the embryonic gut, the epithelium of which is called the anterior foregut endoderm (gray shading, left tube); the numbers underneath give the age of the embryo (in days for mouse embryos and weeks for human embryos). The lung bud epithelium (gray shading, middle tube) emerges from the anterior foregut endoderm and undergoes branching morphogenesis (right tube) to give rise to stalk regions that will become the proximal airways, and a distal tip region that iteratively divides to give rise to more branching airways and eventually to alveoli (enlarged in dashed boxes). The stalk and tip regions have different expression patterns of the Sox2 and Sox9 transcription factors in humans and mice.


Links: Sox | Respiratory System Development | Mouse Development

Reference

Waghray A & Rajagopal J. (2017). Tips from the embryonic lung. Elife , 6, . PMID: 28806170 DOI.

Copyright

© 2017 eLife Sciences Publications Ltd. Subject to a Creative Commons 4.0 Attribution license, except where otherwise noted. ISSN: 2050-084X


Cite this page: Hill, M.A. (2024, June 21) Embryology Lung human and mouse Sox expression.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Lung_human_and_mouse_Sox_expression.jpg

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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current10:10, 31 August 2017Thumbnail for version as of 10:10, 31 August 20171,280 × 692 (62 KB)Z8600021 (talk | contribs)he lung originates from a region of the embryonic gut, the epithelium of which is called the anterior foregut endoderm (gray shading, left tube); the numbers underneath give the age of the embryo (in days for mouse embryos and weeks for human embryos)....