File:Joint Morphogenesis cartoon.jpg

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Joint Morphogenesis - Knee

Longitudinal views depicting key steps in the formation of the knee joint.

  • a - The first sign of a presumptive joint is a condensation of Col2+ limb bud progenitors at the presumptive joint site.
  • b - Joint specification is marked by induction of Gdf5 in the interzone and downregulation of Col2a1.
  • c - A joint space is formed by cavitation after progenitors for a variety of secondary joint structures are specified from the Gdf5+ progenitor pool.
  • d - Maturation of the synovial joint of the knee occurs during development and early postnatal life.
  • e - Schematic representation of a healthy human knee.
  • f - Joint health in adult life is affected by genetics and environmental factors such as nutrition and exercise. Loss of joint homeostasis can trigger degenerative joint diseases such as osteoarthritis, which is characterized by degradation of articular and meniscal cartilage, formation of bone spurs and pain.


OMIM: Col2a1 | Gdf5

Joint Links: joint | synovial joint | temporomandibular joint | musculoskeletal | cartilage | Category:Joint
Historic Embryology  
1940 Synovial Joints | 1952 Mandibular Joint

Reference

Salazar VS, Gamer LW & Rosen V. (2016). BMP signalling in skeletal development, disease and repair. Nat Rev Endocrinol , 12, 203-21. PMID: 26893264 DOI.

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Order Details Licensee: Mark A Hill License Date: Sep 11, 2016 License Number: 3946190772930 Publication: Nature Reviews Endocrinology Title: BMP signalling in skeletal development, disease and repair Type Of Use: post on a website


Cite this page: Hill, M.A. (2024, April 22) Embryology Joint Morphogenesis cartoon.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Joint_Morphogenesis_cartoon.jpg

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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Date/TimeThumbnailDimensionsUserComment
current10:18, 12 September 2016Thumbnail for version as of 10:18, 12 September 2016946 × 907 (160 KB)Z8600021 (talk | contribs)==Joint Morphogenesis== Longitudinal views depicting key steps in the formation of the knee joint. a | The first sign of a presumptive joint is a condensation of Col2+ limb bud progenitors at the presumptive joint site. b | Joint specification is marke...

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