File:Intraepithelial lymphocyte differentiation 03.jpg

From Embryology

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Natural and Induced Intraepithelial Lymphocyte Function

The beneficial roles of natural and induced intraepithelial lymphocytes (IELs) in preserving the epithelium and restoring tissue integrity after injury.

  • Natural IELs - (previously ‘type b’ IELs) acquire activated phenotype during development in the thymus in the presence of self antigens.
  • Induced IELs - (previously ‘type a’ IELs) progeny of conventional T cells activated post-thymically in response to peripheral antigens.

Immune Images: Oesophagus MALT | Colon MALT | Peyer's patch overview | Peyer's patch detail | Cartoon - IEL development | Cartoon - IEL function | Cartoon - IEL differentiation | Mesenteric Lymph Nodes overview | Palatine Tonsil | Tonsil | Immune System Development


<pubmed>21681197</pubmed>| Nat Rev Immunol.


© 2011 Macmillan Publishers Limited. All rights reserved

Licensee: Mark A Hill License Date: Jan 25, 2015 License Number: 3556220285761 Publication: Nature Reviews Immunology Title: The light and dark sides of intestinal intraepithelial lymphocytes Type Of Use: post on a website Figure 1. Nihms307956-23.jpg

Cite this page: Hill, M.A. (2024, June 19) Embryology Intraepithelial lymphocyte differentiation 03.jpg. Retrieved from

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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Yi efo/eka'e gwa ebo wo le nyangagi wuncin ye kamina wunga tinya nan

current14:50, 26 January 2015Thumbnail for version as of 14:50, 26 January 2015600 × 484 (68 KB)Z8600021 (talk | contribs)==Thymic and peripheral differentiation of natural and induced intraepithelial lymphocytes== * IELs - intraepithelial lymphocytes * MLNs - mesenteric lymph nodes * APC - antigen-presenting cell In the thymus, immature CD4+CD8αβ+CD8αα+ (triple pos...

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