File:Intraepithelial lymphocyte differentiation 02.jpg

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Kinetics of the accumulation of natural and induced IELs

Natural intraepithelial lymphocytes (IELs) gain their antigen-experienced phenotype and gut-homing capacity in the thymus during their initial agonist-based selection in response to self antigens.

They populate the gut compartment early, before environmental antigens have been encountered.

Conventional naive T cells differentiate into effector cells in response to peripherally encountered antigens and gradually accumulate over time as antigen-experienced induced IELs in the gut.


Immune Images: Oesophagus MALT | Colon MALT | Peyer's patch overview | Peyer's patch detail | Cartoon - IEL development | Cartoon - IEL function | Cartoon - IEL differentiation | Mesenteric Lymph Nodes overview | Palatine Tonsil | Tonsil | Immune System Development

Reference

<pubmed>21681197</pubmed>| Nat Rev Immunol.

Copyright

© 2011 Macmillan Publishers Limited. All rights reserved

Licensee: Mark A Hill License Date: Jan 25, 2015 License Number: 3556220285761 Publication: Nature Reviews Immunology Title: The light and dark sides of intestinal intraepithelial lymphocytes Type Of Use: post on a website Figure 2.


Cite this page: Hill, M.A. (2024, June 12) Embryology Intraepithelial lymphocyte differentiation 02.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Intraepithelial_lymphocyte_differentiation_02.jpg

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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