File:Intraepithelial lymphocyte differentiation 01.jpg: Difference between revisions

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Thymic and peripheral differentiation of natural and induced intraepithelial lymphocytes

IELs - intraepithelial lymphocytes
MLNs - mesenteric lymph nodes
APC - antigen-presenting cell

In the thymus, immature CD4+CD8αβ+CD8αα+ (triple positive) thymocytes undergo agonist (‘alternative’) selection and differentiate into double-negative T cell receptor-αβ (TCRαβ)+ cells that are the precursors of natural TCRαβ+ intraepithelial lymphocytes (IELs). The TCRαβ+ natural IEL precursor cells partly acquire their antigen-experienced phenotype ‘naturally’ during selection with self antigens.

Precursor cells for TCRαβ+ and TCRγδ+ natural IELs upregulate intestinal homing receptors during their maturation in the thymus, which allows these cells to directly seed the intestinal epithelium after they leave the thymus.

CD4+CD8αβ+ (double positive) thymocytes undergo ‘conventional’ thymic selection and differentiate into naive CD4+ and CD8αβ+ TCRαβ+ T cells that migrate to the periphery.

These naive T cells can differentiate into effector T cells in response to peripheral antigens and subsequently migrate to the gut and become incorporated into the induced IEL compartment.

Reference

<pubmed>21681197</pubmed>| Nat Rev Immunol.

Copyright

Licensee: Mark A Hill License Date: Jan 25, 2015 License Number: 3556220285761 Publication: Nature Reviews Immunology Title: The light and dark sides of intestinal intraepithelial lymphocytes Type Of Use: post on a website Figure 1. Nihms307956-23.jpg (text from original figure legend)

Cite this page: Hill, M.A. (2024, May 28) Embryology Intraepithelial lymphocyte differentiation 01.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Intraepithelial_lymphocyte_differentiation_01.jpg

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	Date/Time	Thumbnail	Dimensions	User	Comment
current	13:54, 26 January 2015		1,200 × 585 (108 KB)	Z8600021 (talk \| contribs)	==Thymic and peripheral differentiation of natural and induced intraepithelial lymphocytes== IELs - intraepithelial lymphocytes In the thymus, immature CD4+CD8αβ+CD8αα+ (triple positive) thymocytes undergo agonist (‘alternative’) selection an...

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Immune System Development

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@@ Line 7: / Line 7: @@
 In the thymus, immature CD4+CD8αβ+CD8αα+ (triple positive) thymocytes undergo agonist (‘alternative’) selection and differentiate into double-negative T cell receptor-αβ (TCRαβ)+ cells that are the precursors of natural TCRαβ+ intraepithelial lymphocytes (IELs). The TCRαβ+ natural IEL precursor cells partly acquire their antigen-experienced phenotype ‘naturally’ during selection with self antigens.
-Precursor cells for TCRαβ+ and TCRγδ+ natural IELs upregulate intestinal homing receptors during their maturation in the thymus, which allows these cells to directly seed the intestinal epithelium after they leave the thymus. CD4+CD8αβ+ (double positive) thymocytes undergo ‘conventional’ thymic selection and differentiate into naive CD4+ and CD8αβ+ TCRαβ+ T cells that migrate to the periphery.
+Precursor cells for TCRαβ+ and TCRγδ+ natural IELs upregulate intestinal homing receptors during their maturation in the thymus, which allows these cells to directly seed the intestinal epithelium after they leave the thymus.
+CD4+CD8αβ+ (double positive) thymocytes undergo ‘conventional’ thymic selection and differentiate into naive CD4+ and CD8αβ+ TCRαβ+ T cells that migrate to the periphery.
 These naive T cells can differentiate into effector T cells in response to peripheral antigens and subsequently migrate to the gut and become incorporated into the induced IEL compartment.
@@ Line 24: / Line 26: @@
 Publication: Nature Reviews Immunology
 Title: The light and dark sides of intestinal intraepithelial lymphocytes
-Type Of Use: post on a website Figure 1.  Nihms307956-23.jpg
+Type Of Use: post on a website Figure 1.  Nihms307956-23.jpg (text from original figure legend)
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 [[Category:Immune]] [[Category:Gastrointestinal Tract]][[Category:Cartoon]]