File:Intraepithelial lymphocyte differentiation 01.jpg: Difference between revisions

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Thymic and peripheral differentiation of natural and induced intraepithelial lymphocytes

IELs - intraepithelial lymphocytes
MLNs - mesenteric lymph nodes
APC - antigen-presenting cell

In the thymus, immature CD4+CD8αβ+CD8αα+ (triple positive) thymocytes undergo agonist (‘alternative’) selection and differentiate into double-negative T cell receptor-αβ (TCRαβ)+ cells that are the precursors of natural TCRαβ+ intraepithelial lymphocytes (IELs). The TCRαβ+ natural IEL precursor cells partly acquire their antigen-experienced phenotype ‘naturally’ during selection with self antigens.

Precursor cells for TCRαβ+ and TCRγδ+ natural IELs upregulate intestinal homing receptors during their maturation in the thymus, which allows these cells to directly seed the intestinal epithelium after they leave the thymus.

CD4+CD8αβ+ (double positive) thymocytes undergo ‘conventional’ thymic selection and differentiate into naive CD4+ and CD8αβ+ TCRαβ+ T cells that migrate to the periphery.

These naive T cells can differentiate into effector T cells in response to peripheral antigens and subsequently migrate to the gut and become incorporated into the induced IEL compartment.

Reference

Cheroutre H, Lambolez F & Mucida D. (2011). The light and dark sides of intestinal intraepithelial lymphocytes. Nat. Rev. Immunol. , 11, 445-56. PMID: 21681197 DOI.

Copyright

Licensee: Mark A Hill License Date: Jan 25, 2015 License Number: 3556220285761 Publication: Nature Reviews Immunology Title: The light and dark sides of intestinal intraepithelial lymphocytes Type Of Use: post on a website Figure 1. Nihms307956-23.jpg (text from original figure legend)

Cite this page: Hill, M.A. (2024, May 28) Embryology Intraepithelial lymphocyte differentiation 01.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Intraepithelial_lymphocyte_differentiation_01.jpg

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current	13:54, 26 January 2015		1,200 × 585 (108 KB)	Z8600021 (talk \| contribs)	==Thymic and peripheral differentiation of natural and induced intraepithelial lymphocytes== IELs - intraepithelial lymphocytes In the thymus, immature CD4+CD8αβ+CD8αα+ (triple positive) thymocytes undergo agonist (‘alternative’) selection an...

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Immune System Development

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@@ Line 1: / Line 1: @@
 ==Thymic and peripheral differentiation of natural and induced intraepithelial lymphocytes==
-IELs - intraepithelial lymphocytes
+* IELs - intraepithelial lymphocytes
+* MLNs - mesenteric lymph nodes
+* APC - antigen-presenting cell
-In the thymus, immature CD4+CD8αβ+CD8αα+ (triple positive) thymocytes undergo agonist (‘alternative’) selection and differentiate into double-negative T cell receptor-αβ (TCRαβ)+ cells that are the precursors of natural TCRαβ+ intraepithelial lymphocytes (IELs). The TCRαβ+ natural IEL precursor cells partly acquire their antigen-experienced phenotype ‘naturally’ during selection with self antigens. In addition, the precursor cells for TCRαβ+ and TCRγδ+ natural IELs upregulate intestinal homing receptors during their maturation in the thymus, which allows these cells to directly seed the intestinal epithelium after they leave the thymus. CD4+CD8αβ+ (double positive) thymocytes undergo ‘conventional’ thymic selection and differentiate into naive CD4+ and CD8αβ+ TCRαβ+ T cells that migrate to the periphery. These naive T cells can differentiate into effector T cells in response to peripheral antigens and subsequently migrate to the gut and become incorporated into the induced IEL compartment. APC, antigen-presenting cell; MLNs, mesenteric lymph nodes.
+In the thymus, immature CD4+CD8αβ+CD8αα+ (triple positive) thymocytes undergo agonist (‘alternative’) selection and differentiate into double-negative T cell receptor-αβ (TCRαβ)+ cells that are the precursors of natural TCRαβ+ intraepithelial lymphocytes (IELs). The TCRαβ+ natural IEL precursor cells partly acquire their antigen-experienced phenotype ‘naturally’ during selection with self antigens.
+Precursor cells for TCRαβ+ and TCRγδ+ natural IELs upregulate intestinal homing receptors during their maturation in the thymus, which allows these cells to directly seed the intestinal epithelium after they leave the thymus.
-Figure 1.  Nihms307956-23.jpg
+CD4+CD8αβ+ (double positive) thymocytes undergo ‘conventional’ thymic selection and differentiate into naive CD4+ and CD8αβ+ TCRαβ+ T cells that migrate to the periphery.
+These naive T cells can differentiate into effector T cells in response to peripheral antigens and subsequently migrate to the gut and become incorporated into the induced IEL compartment.
+{{Immune Images 2}}
 ===Reference===
-<pubmed>21681197</pubmed>| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140792 Nat Rev Immunol.]
+{{#pmid:21681197}}
 ====Copyright====
@@ Line 19: / Line 26: @@
 Publication: Nature Reviews Immunology
 Title: The light and dark sides of intestinal intraepithelial lymphocytes
-Type Of Use: post on a website
+Type Of Use: post on a website Figure 1.  Nihms307956-23.jpg (text from original figure legend)
+{{Footer}}
 [[Category:Immune]] [[Category:Gastrointestinal Tract]][[Category:Cartoon]]