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Thymic and peripheral differentiation of natural and induced intraepithelial lymphocytes

  • IELs - intraepithelial lymphocytes
  • MLNs - mesenteric lymph nodes
  • APC - antigen-presenting cell

In the thymus, immature CD4+CD8αβ+CD8αα+ (triple positive) thymocytes undergo agonist (‘alternative’) selection and differentiate into double-negative T cell receptor-αβ (TCRαβ)+ cells that are the precursors of natural TCRαβ+ intraepithelial lymphocytes (IELs). The TCRαβ+ natural IEL precursor cells partly acquire their antigen-experienced phenotype ‘naturally’ during selection with self antigens.

Precursor cells for TCRαβ+ and TCRγδ+ natural IELs upregulate intestinal homing receptors during their maturation in the thymus, which allows these cells to directly seed the intestinal epithelium after they leave the thymus.

CD4+CD8αβ+ (double positive) thymocytes undergo ‘conventional’ thymic selection and differentiate into naive CD4+ and CD8αβ+ TCRαβ+ T cells that migrate to the periphery.

These naive T cells can differentiate into effector T cells in response to peripheral antigens and subsequently migrate to the gut and become incorporated into the induced IEL compartment.


Immune Images: Oesophagus MALT | Colon MALT | Peyer's patch overview | Peyer's patch detail | Cartoon - IEL development | Cartoon - IEL function | Cartoon - IEL differentiation | Mesenteric Lymph Nodes overview | Palatine Tonsil | Tonsil | Immune System Development

Reference

Cheroutre H, Lambolez F & Mucida D. (2011). The light and dark sides of intestinal intraepithelial lymphocytes. Nat. Rev. Immunol. , 11, 445-56. PMID: 21681197 DOI.

Copyright

© 2011 Macmillan Publishers Limited. All rights reserved

Licensee: Mark A Hill License Date: Jan 25, 2015 License Number: 3556220285761 Publication: Nature Reviews Immunology Title: The light and dark sides of intestinal intraepithelial lymphocytes Type Of Use: post on a website Figure 1. Nihms307956-23.jpg (text from original figure legend)


Cite this page: Hill, M.A. (2024, February 26) Embryology Intraepithelial lymphocyte differentiation 01.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Intraepithelial_lymphocyte_differentiation_01.jpg

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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current14:54, 26 January 2015Thumbnail for version as of 14:54, 26 January 20151,200 × 585 (108 KB)Z8600021 (talk | contribs)==Thymic and peripheral differentiation of natural and induced intraepithelial lymphocytes== IELs - intraepithelial lymphocytes In the thymus, immature CD4+CD8αβ+CD8αα+ (triple positive) thymocytes undergo agonist (‘alternative’) selection an...

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