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Human spermatozoa chemotaxis model

Molecular mechanisms involved in the sperm chemotaxis mediated by progesterone.

1, P-PR interaction; 2, tmAC activation and cAMP synthesis; 3, PKA activation; 4, protein phosphorylation; 5, stored Ca2+ released through IP3R channel; 6, first Ca2+ influx through SOC channel; 7, activation of sGC with an intracellular cGMP increase; 8, PKG activation and a second Ca2+ influx probably through other calcium channels; 9, change in sperm swimming direction. Data from this study are shown with black arrows while unknown connecting steps are marked with red arrows. See text for further explanation of the model.

Links: Chemotaxis Model | Labeled Chemotaxis Model | Spermatozoa Development | Fertilization

Reference

<pubmed>19997608</pubmed>| PLoS One.

Copyright

© 2009 Teves et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Figure 6. doi:10.1371/journal.pone.0008211.g006 Original figure altered in size and labelling.

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