File:Human fetal ovary FOXL2.jpg

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Human Fetal Ovary FOXL2

Immunolocalization of FOXL2 in the human fetal ovary.

  • A and B - 14 weeks (GA).
  • C and D - 19 weeks (GA).

Positive immunofluorescence for FOXL2 is green, counterstain is propidium iodide (red), hence nuclear FOXL2 is yellow. Inset in (A) is negative control.

  • E and F - Double immunofluorescence for FOXL2 (green) and OCT4 (red) in human fetal ovary showing absence of colocalization, with FOXL2 expressed by somatic cells and OCT4 by germ cells.
    • E - 9 weeks (GA).
    • F - 19 weeks (GA).

Legend

  • Blue - DAPI nuclear stain
  • G - germ cell
  • S - somatic cell.

Scale bars are 50 µm (A, applies to E and F) or 10 µm (B, C, D).


Links: Ovary Development

Reference

Duffin K, Bayne RA, Childs AJ, Collins C & Anderson RA. (2009). The forkhead transcription factor FOXL2 is expressed in somatic cells of the human ovary prior to follicle formation. Mol. Hum. Reprod. , 15, 771-7. PMID: 19706741 DOI.

Citation: The forkhead transcription factor FOXL2 is expressed in somatic cells of the human ovary prior to follicle formation. Duffin K, Bayne RA, Childs AJ, Collins C, Anderson RA. Mol Hum Reprod. 2009 Dec;15(12):771-7. Epub 2009 Aug 25.

"In summary, the expression of FOXL2 in somatic cells of the developing human ovary before and during follicle formation supports a conserved and continuing role for this factor in somatic/germ cell interactions from the earliest stages of human ovarian development."
  • FOXL2 gene are associated with syndromic and non-syndromic ovarian failure.
  • Mutations in FOXL2 result in blepharophimosis/ptosis/epicanthus inversus syndrome (BPES).
  • FOXL2 is a member of the winged helix/forkhead transcription factor family (39 known members) variety of functions acting as transcriptional activators and repressors.

Copyright

© The Author 2009.

Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.


Original File name: Figure 2 - gap06502.jpeg


Cite this page: Hill, M.A. (2024, May 29) Embryology Human fetal ovary FOXL2.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Human_fetal_ovary_FOXL2.jpg

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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current10:06, 3 May 2010Thumbnail for version as of 10:06, 3 May 2010739 × 1,087 (300 KB)S8600021 (talk | contribs)Immunolocalization of FOXL2 in the human fetal ovary. A and B, 14 weeks; C and D, 19 weeks. Positive immunofluorescence for FOXL2 is green, counterstain is propidium iodide (red), hence nuclear FOXL2 is yellow. Inset in (A) is negative control. (E, F)