File:Human cochlea fetal development cartoon.jpg

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Human Cochlea Fetal Development Cartoon

Schematic diagram of neurosensory development in the basal turn of the human fetal cochlea by Gestational Week GA

Gestational Week GA

  • Week 10 (W10) - SOX2 identifies the prosensory domain within the SOX9/SOX10+ cochlear duct epithelium. Neurites from the adjoining TUBB3+/PRPH + SGNs do not yet penetrate into the epithelium.
  • Week 11 (W11) - Penetration starts prior to hair cell differentiation.
  • Week 12 (W12) - The first MYO7A+/SOX9-/SOX10-/SOX2+ (inner) hair cell can be seen, and is contacted by multiple TUBB3+ and PRPH + neurites. Penetrating neurites are also found at the location of the future OHCs.
  • Week 14 (W14) - Both the IHCs and OHCs have differentiated, and neurites underneath the OHCs start to run in a spiral direction. At this stage, hair cells still express SOX2.
  • Week 20 (W20) - SOX2 is downregulated in all hair cells, as opposed to the other cells in the organ of Corti. PRPH expression distinguishes between type I (PRPH-) and type II (PRPH+) neurites.
Abbreviations
  • SGN - spiral ganglion neuron
  • IHC - inner hair cell
  • O1 - first row of outer hair cells
  • O2 - second row of outer hair cells
  • O3 - third row of outer hair cells
  • OHC - outer hair cell.


Cochlea Links: Image week 8 | Image week 10 | Cochlea molecular cartoon | Inner Ear Development


Reference

Locher H, Frijns JH, van Iperen L, de Groot JC, Huisman MA & Chuva de Sousa Lopes SM. (2013). Neurosensory development and cell fate determination in the human cochlea. Neural Dev , 8, 20. PMID: 24131517 DOI.

Copyright

© 2013 Locher et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Figure 9. 1749-8104-8-20-9.jpg Locher et al. Neural Development 2013 8:20 doi:10.1186/1749-8104-8-20 Original figure altered in size and labelling.


Cite this page: Hill, M.A. (2024, June 24) Embryology Human cochlea fetal development cartoon.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Human_cochlea_fetal_development_cartoon.jpg

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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