File:HansonAnson1962 fig04.jpg

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Fig. 4. Fetus 15 week 115 mm

a, In the 15-week fetus (115 mm.) the malleus begins to ossify from a single center located medially, nee the neck of the ossicles. The incus, at this level, is almost completely surrounded by a perichondral ayer.

Although the maximum growth of Meckel’s cartilage is not attained until the 17-or-18-week stage, the cartilage at the periphery of the bar shows early evidence of degeneration in the stage here illustrated.

b, Detailed examination (of the area blocked in a) reveals a layer of osteoblasts which will lay down a plaque of perichondral bone. This will spread rapidly over the ossicle. Calcification of cartilage matrix and primary resorption will ensue prior to actual endochondral ossification.

c, The cells near the periphery of Meckel’s cartilage (in the rectangular portion of a) flatten and assume an arrangement parallel to the surface of the bar. This stage in differentiation precedes their conversion into the fibrous tissue of the anterior ligament of the malleus.


Hanson JR. and Anson BJ. Development of the malleus of the human ear; Illustrated in atlas series. (1962) Q Bull Northwest Univ Med Sch. 36(2): 119–137. PMID: 13904457.

Cite this page: Hill, M.A. (2024, April 15) Embryology HansonAnson1962 fig04.jpg. Retrieved from

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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